Department: Department of Mathematical Sciences
Job Title: Professor of Statistics
Telephone: +44 1225 385674
E-mail Address: C.Jennison@bath.ac.uk
Postal Address:
Book
Group Sequential Methods with Applications to Clinical Trials by Christopher Jennison and Bruce W. Turnbull.
Publications
Full list of publications: pdf file
Diabetes Research
I am an invesitgator in the DIRECT research project, funded by the EU Innovative Medicines Initiative.
Short courses
List of half-day, one-day and two-day short courses on Group Sequential and Adaptive Clinical Trials
Recent talks
Seminar at University of York, May 2013 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping" pdf file
Seminar at Roche, Welwyn Garden City, May 2013 "Adaptive Sample Size Modification in Clinical Trials: Start Small then Ask for More?" pdf file,
Talk by C. Jennison and B. W. Turnbull at SMi conference: Adaptive Designs in Clinical Trials, London, April 2013 "Adaptive Sample Size Modification in Clinical Trials: Start Small then Ask for More?" pdf file, ppt file
Talk at Workshop on Special Topics on Sequential Methodology, University Medical Centre Utrecht, March 2013 "Group Sequential Tests for Delayed Responses" pdf file
Seminar at Cambridge University, November 2012 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping" pdf file
Seminar at Lancaster University, October 2012 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file
Slides for PSI Workshop: Latimer House, October 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Talk by C. Jennison and L. V. Hampson at BfArM/DIA Statistics Workshop, Bonn, October 2012 "Group Sequential Tests for Delayed Responses". pdf file, ppt file
Talk at GSK, BAC Conference, Ware, October 2012 "Effective design of Phase II and Phase III trials: an over-arching approach". pdf file
Talk at Recent Advances in Adaptive Designs organised by PSI and Aptiv Solutions, London, July 2012 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file
Paper by L. V. Hampson and C. Jennison read to the Royal Statistical Society, at a meeting organised by the Research Section, 16 May 2012 "Group Sequential Tests for Delayed Responses". pdf file
Talk at PSI conference: The Belfry, May 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, March 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Seminar at Chalmers University, Gothenburg, January 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Talk at AstraZeneca, Molndal, Sweden, January 2012 "The roles of short term endpoints in clinical trial planning and design" pdf file
Seminar at GSK, Stevenage, December 2011 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file
Seminar at Roche, Welwyn Garden City, December 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Seminar at University of Bath, December 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Tutorial at Biopharmaceutical Applied Statistics Symposium (BASS) XVIII, Savannah, Georgia, November 2011 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file
Talk at Workshop on the Design and Analysis of Clinical Trials, Institute for Mathematical Sciences, National University of Singapore, October 2011 "Group sequential and adaptive clinical trials". pdf file
Talk at 2nd Conference of the Central European Network --- CEN 2011, Zurich, September 2011 "Adaptive population enrichment: switching to a sub-population in response to interim trial data". pdf file
Talk at ADAPT conference on Adaptive Clinical Trials, Philadelphia, September 2011 "Effective design of Phase II and Phase III trials: an over-arching approach". pdf file
Talk at workshop on Design of Experiments in Healthcare, Isaac Newton Institute, Cambridge, August 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Talk at 3rd International Workshop in Sequential Methodologies, Stanford, June 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file
Talk at Royal Netherlands Academy of Arts and Sciences colloquium "Cost Efficient and Optimal Designs for Social and Biomedical Sciences", Amsterdam, April 2011 "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping". pdf file
Talk at Challenges in Statistics and Operations Research Conference: Kuwait, March 2011 "Decision theory, dynamic programming and optimal stopping of clinical trials". pdf file
Talk at 2nd International Symposium on Biopharmaceutical Statistics: Berlin, March 2011 "Optimising the PhaseIIb, Phase III process". pdf file
Seminar at Durham University, February 2011 "Data combination in seamless Phase II/III designs". pdf file
Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, February 2011 "Statistical inference after group sequential and adaptive clinical trials". pdf file
Seminar at University of Leeds, November 2010 "Data combination in seamless Phase II/III designs". pdf file
Seminar at Medical University of South Carolina, Charleston, SC, October 2010 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file
Seminar at Chalmers University, Gothenburg, August 2010 "Data combination in seamless Phase II/III designs". pdf file
Talk at AstraZeneca, Molndal, Sweden, August 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file
Talk at IMS 73rd Annual Meeting, Gothenburg, Sweden, August 2010 "Decision theory, dynamic programming and optimal stopping of clinical trials". pdf file
Seminar at Merck Serono, Geneva, Switzerland, June 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file
Seminar at Children's Oncology Group, Los Angeles, February 2010 "Group Sequential and Adaptive Designs: Where are we now?" (with additional material on short term/surrogate endpoints) pdf file
Seminar at City of Hope, Duarte, California, February 2010 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file
Seminar at City of Hope, Duarte, California, February 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file
Talk at VIB Adaptive Trials 2009 Conference, Brussels, December 2009 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file
Seminar at University of Kent, December 2009 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping". pdf file
Talk at 6th International Meeting on Statistical Methods in Biopharmacy, Paris, September 2009 "Group Sequential and Adaptive Designs: Where are we now?" pdf file
ACRP Webinar, September 2009 "Adaptive Clinical Trials: What do they Offer?" pdf file
Contribution to panel discussion, Joint Statistical Meetings, Washington DC, August 2009 "Adaptive Design: Where Are We Now?" pdf file
Talk at 2009 Quality & Productivity Research Conference, IBM T. J. Watson Research Center, Yorktown Heights, New York, June 2009 "Data Combination in Seamless Phase II/III Designs". pdf file
Talk at 6th International Conference on Multiple Comparison Procedures, Tokyo, March 2009 "Data Combination in Seamless Phase II/III Designs". pdf file
Talk at Pfizer, Sandwich, UK, February 2009 "Critical Appraisal of Adaptive Methods". pdf file
Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, February 2009 "Critical Appraisal of Adaptive Methods". pdf file
Seminar at University of Bath, December 2008 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping". pdf file
Talk at European Leukaemia Network Workshop, Munich, October 2008 "Adaptive sample size re-estimation". pdf file
Talk in KOL lecture series: September 2008 "Comparing Adaptive Designs and the Classical Group Sequential Approach to Clinical Trial Design". pdf file
Talk at VIB conference: Adaptive Trials 2008, Barcelona, September 2008 "Critical Appraisal of Adaptive Methods". pdf file
Talk at Joint Statistical Meetings, Denver, August 2008 "Adaptive designs: Why, how and when?". pdf file
Talk at ISBS Conference, Shanghai, July 2008 "Adaptive designs: Why, how and when?". pdf file
Talk at Informa Conference, Adaptive Designs for Clinical Development, London, May 2008 "Comparing adaptive designs and the classical, sequential approach". pdf file
Talk at ENAR Biometrics Conference, Arlington, March 2008 "Adaptive designs: Why, how and when?". pdf file
Recent papers
"Group sequential tests for delayed responses" by Lisa Hampson and Christopher Jennison. pdf file. This paper will be read at a meeting of the Research Section of the Royal Statistical Society on 16 May, 2012.
"Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by Christopher Jennison and Bruce W. Turnbull. pdf file (a version of this paper will appear in Proceedings of the International Conference on Challenges in Statistics and Operations Research, Kuwait, March 2011 .
"An adaptive seamless design with subpopulation selection" by Martin Jenkins, Andrew Stone and Christopher Jennison. word file (a revised version of this paper is online and will soon appear in print in Pharmaceutical Statistics, 2011, doi: 10.1002/pst.472).
"Mapping electron density in the ionosphere: a principal component MCMC algorithm" by Eman Khorsheed, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Computational Statistics and Data Analysis, 2011, 338-352; doi:10.1016/j.csda.2010.04.029).
"Three dimensional statistical image analysis and confocal microscopy" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Journal of Applied Statistics, 2011, 29-46; doi: 10.1080/02664760903117747).
"From group sequential to adaptive designss" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in Handbook of Adaptive Design in Pharmaceutical and Clinical Development, eds. A. Pong and S.-C. Chow, New York: CRC Press, 5-1 - 5-25, 2011).
"Optimal group sequential designs for simultaneous testing of superiority and non-inferiority" by Fredrik Ohrn and Christopher Jennison. pdf file (a revised version of this paper is in Statistics in Medicine, 2010, 743-759; doi: 10.1002/sim.3790).
"Comparing efficiency for adaptive and non-adaptive group sequential designs" by Bruce W. Turnbull and Christopher Jennison. pdf file (a revised version of this paper is in Proceedings of the 57th ISI conference, Durban, South Africa, August 2009 .
"Adaptive seamless designs: Selection and prospective testing of hypotheses" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in J. Biopharmaceutical Statistics, 2007, 1135-1161; doi: 10.1080/10543400701645215).
"Adaptive and non-adaptive group sequential tests" by Christopher Jennison and Bruce W. Turnbull. This paper derives theory of optimal adaptive and non-adaptive group sequential designs, extending the theoretical results of Tsiatis and Mehta (Biometrika, 2003) and explaining the implications of this theory. It also gives numerical results showing the relative efficiency of the best possible adaptive and non-adaptive designs: pdf file (a revised version of this paper is in Biometrika, 2006, 1-21; doi: 10.1093/biomet/93.1.1).
"Efficient group sequential designs when there are several effect sizes under consideration" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in Statistics in Medicine, 2006, 917-932; doi: 10.1002/sim.2251). Technical report with additional tables: pdf file
"Meta-analyses and adaptive group sequential designs in the clinical development process" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in J. Biopharmaceutical Statistics, 2005, 537-558; doi: 10.1081/bip-200062273).
"Improving the acceptance rate of reversibe jump MCMC proposals" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Statistics and Probability Letters, 2004, Vol 69, 189-198; doi: 10.1002/sim.1457)
"Statistical image analysis for a confocal microscopy 2D section of cartilage growth" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Applied Statistics, 2004, 31-49; doi: 0035.9254/04/53031)
"Mid-course sample size modification in clinical trials based on the observed treatment effect" by Christopher Jennison and Bruce W. Turnbull presented at 4th International Meeting on Statistical Methods in Biopharmacy, Paris, September 2001: pdf file (a revised version of this paper is in Statistics in Medicine, 2003, 971-993; doi: 10.1002/sim.1457).
Associate Editor of
Committee member of the Bradford on Avon Film Society.
Bradford on Avon Thai Festival and cookery competition photos (all) or (selected).
Sentosa photos.