Publications
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2024
Radrizzani, S., Kudla, G., Izsvák Z., Hurst, L.D. (2024) Selection on synonymous sites: the unwanted transcript hypothesis. Nature Reviews Genetics https://doi.org/10.1038/s41576-023-00686-7
Taylor AJ, Yahara K, Pascoe B, Ko S, Mageiros L, Mourkas E, Calland JK, Puranen S, Hitchins MD, Jolley KA, Kobras CM, Bayliss S, Williams NJ, van Vliet AHM, Parkhill J, Maiden MCJ, Corander J, Hurst LD, Falush D, Keim P, Didelot X, Kelly DJ, Sheppard SK. 2024. Epistasis, core-genome disharmony, and adaptation in recombining bacteria. mBio 0:e00581-24.
2023
Wang, L., Ho, A.T., Hurst, L.D.*, Yang, S.* (2023) . Nature 619 E52-E56
Lewin, L.E., Daniels, K.G. and Hurst, L.D. (2023) . Plos Computational Biology 19 (10), e1011581 doi.org/10.1371/journal.pcbi.1011581
Singh M, Kondrashkina AM, Widmann TJ, Cortes JL, Bansal V, Wang J, Römer C, Garcia-Canadas M, Garcia-Perez JL*, Hurst LD*, Izsvák Z.* (2023) A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass. Public Library of Science, Biology 2023;21(6):e3002162. doi: 10.1371/journal.pbio.3002162. For Primer see here. Genes for highly abundant proteins in Escherichia coli avoid 5’ codons that promote ribosomal initiation Re-evaluating evidence for adaptive mutation rate variation
Singh M, Kondraskhina AM, Hurst LD, Izsvák Z.(2023) Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH. The Journal of Clinical Investigation. 133 :e172278 doi: 10.1172/JCI172278 (commentary)
Fonseca, C., Pettitt, J., Woollard, A., Rutherford, A., Bickmore, W., Ferguson-Smith, A., Hurst, L.D. (2023) People with more extreme attitudes towards science have self-confidence in their understanding of science, even if this isn’t justified. Public Library of Science, Biology 21(1): e3001915.
Richer S., Tian Y., Schoenfelder S., Hurst L., Murrell A., Pisignano G. (2023) Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters. Genome Biology 24(1):40. doi: 10.1186/s13059-023-02876-2.
Radrizzani, S., Fonseca, C., Pettitt, J., Woollard, A., Hurst, L.D. (2023) Both trust in, and polarization of trust in, relevant sciences have increased through the COVID-19 pandemic. PLoS ONE 18(3): e0278169. https://doi.org/10.1371/journal.pone.0278169
2022
Ho, A.T. and Hurst, L.D. (2022) Stop codon usage as a window into genome evolution: mutation, selection, biased gene conversion and the TAG paradox. Genome Biology and Evolution doi.org/10.1093/gbe/evac115
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek ,O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T., Prigione, A., Hurst, L.D.*, Izsvák, Z.* (2022). A novel gene controls a new structure: PiggyBac Transposable Element-Derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles. Molecular Biology and Evolution 39: msac175.
Yu, H., M. Chen, Y. Hu, S. Ou, X. Yu, S. Liang, N. Li, M. Yang, X. Kong, C. Sun, S. Jia, Q. Zhang, L. Liu, L. D. Hurst, R. Li, W. Wang and J. Wang (2022) Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development. Cell Stem Cell 29: 1031-1050.e1012. News and Views here
Hurst, L.D. (2022) Selfish centromeres and the wastefulness of human reproduction. Public Library of Science, Biology 20 e3001671
Ho, A.T. and Hurst, L.D. (2021) Unusual mammalian usage of TGA stop codons reveals that sequence conservation need not imply purifying selection. Public Library of Science, Biology 20(5) e3001588
Mühlhausen, S. and Hurst, L.D. (2022) Transgene-design: a web application for the design of mammalian transgenes. Bioinformatics btac139
Jia, Y., Qin, C., Traw, M.B., Chen, X., He, Y., Kai, J., Yang, S. Wang, L., Hurst, L.D. (2022) In rice splice variants that restore the reading frame after frameshifting indel introduction are common, often induced by the indels and sometimes lead to organism-level rescue. PLoS Genetics 18 e1010071
Vance, Z., Niezabitowski, L., Hurst, L.D. and McLysaght, A. (2022) Evidence from Drosophila supports higher duplicability of faster evolving genes. Genome Biology and Evolution 14 evac003
2021
Ho, A.T. and Hurst, L.D. (2021) Variation in release factor abundance is not needed to explain trends in bacterial stop codon usage. Molecular Biology and Evolution 39 msab326
Abrahams, L., Savisaar, R., Mordstein, C., Young, B. Kudla, G., Hurst, L.D. (2021) Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption. Nucleic Acids Research 49 9665-9685 doi.org/10.1093/nar/gkab750
Morales, A.C., Rice, A.M., Ho, A., Mordstein, C., Mühlhausen, S., Watson, S., Cano, L., Young, B, Kudla, G. and Hurst, L.D. (2021) Causes and consequences of purifying selection on SARS-CoV-2 Genome Biology and Evolution 13 evab196
Jia, X., Zhang, Q., Jiang, M., Huang, J., Yu, L., Traw, M.B., Tian, D., Hurst, L.D. and Yang, S. (2021) Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation. Public Library of Science, Biology 19 e3001164
de Oliveira, J.L., Morales, A.C.,Hurst, L.D., Urrutia, A.O., Thompson, C.R.L. and Wolf, J.B. (2021) Inferring adaptive codon preference to understand sources of selection shaping codon usage bias. Molecular Biology and Evolution 38 3247-3266
Mordstein C, Cano L, Morales AC, Young B, Ho AT, Rice AM, Liss M, Hurst LD, Kudla G. (2021). Transcription, mRNA export and immune evasion shape the codon usage of viruses. Genome Biology and Evolution doi.org/10.1093/gbe/evab106
2020
Buchan, L., Hejmadi, M., Abrahams, L. and Hurst, L.D. (2020) A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal. npj Science of Learning 5, 19
Ho, A and Hurst L.D. (2020) Effective population size predicts local rates not local mitigation of read-through errors in eukaryotic genes. Molecular Biology and Evolution 38 244-262
Rice, A.M., Morales, A.C., Ho, A., Mordstein, C., Mühlhausen, S., Watson, S., Cano, L., Young, B, Kudla, G. and Hurst, L.D. (2020) Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design. Molecular Biology and Evolution 38 67-83
Nuetzmann, H-W., Doerr, D., Ramirez-Colmenero, A., Sotelo-Fonseca, J.E., Wegel, E., di Stefano, M., Wingett, S.W., Fraser, P., Hurst, L.D., Fernandez-Valverde, S.L., Osbourn, A. (2020) Active and repressed biosynthetic gene clusters have spatially distinct chromosome states. Proceedings of the National Academy of Sciences, USA 117 13800-13809
Wang, L., Sun, Y., Sun, X, Yu, L., Xue, L., He, Z., Huang, J., Tian, D, Hurst, L.D., Yang, S (2020) Repeat-Induced Point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life. Genome Biology 21 142.
Mordstein, C., Savisaar, R., Young, R.S., Bazile, J., Talmane, L., Luft, J., Liss, M., Taylor, M.S., Hurst, L.D. and Kudla, G. (2020) Codon Usage and Splicing Jointly Influence mRNA Localization. Cell Systems https://10.1016/j.cels.2020.03.001
2019
Abrahams, L. and Hurst, L.D. (2019) A depletion of stop codons in lincRNA is owing to transfer of selective constraint from coding sequences. Molecular Biology and Evolution 37, 1148-1164 https://doi.org/10.1093/molbev/msz299
Ho, A.T. and Hurst, L.D. (2019) In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3’ additional stop codons. PLoS Genetics 15(9): e1008386. https://doi.org/10.1371/journal.pgen.1008386
de Oliveira, J.L., Morales, A.C., Stewart, B., Gruenheit, N., Engelmoer, J., Brown, S.B., de Brito, R.A., Hurst, L.D., Urrutia, A.O., Thompson, C.R.L., Wolf, J.B. (2019) Conditional expression explains molecular evolution of social genes in a microbe. Nature Communications 10, 3284, DOI: 10.1038/s41467-019-11237-2
Wang, L., Ji, Y., Hu, Y, Hu, H., Jia, X., Jiang, M., Zhang, X., Zhao, L., Zhang, Y., Jia, Y., Qin, C., Yu, L., Huang, J., Yang, S.*, Hurst, L.D.*, Tian, D.* (2019) The architecture of intra-organism mutation rate variation in plants. Public Library of Science, Biology 17(4) e3000191 https://doi.org/10.1371/journal.pbio.3000191
Hurst, L.D. (2019) A century of bias in genetics and evolution. Heredity 123 33-43 - invited centenary review
2018
Huang, J., Li, J., Zhou, J., Wang, L., Yang, S., Hurst, L.D.*, Li, W-H* and Tian, D.* (2018) Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout. Proceedings of the National Academy of Sciences, USA 115 7559-7567
Savisaar, R. and L.D. Hurst (2018) Exonic splice regulation imposes strong selection at synonymous sites. Genome Research 28 1442-1454.
Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O’Neill AJ, Murray E, Williams P, Lubben A, Reeksting S, Meric G, Pascoe B, Sheppard SK, Recker M, Hurst LD, Massey RC. (2018) Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA. Genome Biology19 94.
Muehlhausen, S. Schmitt, H.D., Pan, K-T, Plessmann, U., Urlaub, H., Hurst, L.D. and Kollmar, M. (2018) Endogenous stochastic decoding of the CUG codon by competing Ser- and Leu- tRNAs in Ascoidea asiatica. Current Biology 28 2046-2057
Abrahams, L. and Hurst, L.D. (2018) Refining the ambush hypothesis: evidence that GC and AT rich bacteria employ different frameshift defence strategies. Genome Biology and Evolution 10 1153-1173
Mead, R, Hejmadi, M, and Hust, L.D. (2018) Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts. Nature Ecology and Evolution doi:10.1038/s41559-017-0442-x
O’Toole, A. Hurst, L.D.* and McLysaght, A.* (2018) Faster evolving primate genes are more likely to duplicate. Molecular Biology and Evolution 35 107-118 *co-corresponding authors
2017
Liu, H., Huang, J., Sun, X, Li, J, Hu, Y., Yu, L., Liti, G., Tian, D., Hurst, L.D.* and Yang, S.* (2017) Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias. Nature Ecology and Evolution doi:10.1038/s41559-017-0372-7 *co-corresponding authors.
Hurst, L.D. and Batada, N. (2017) Depletion of somatic mutations in splicing-associated sequences in cancer genomes. Genome Biology18 213
Zadora, J., Singh, M., Herse, F., Przybyl, L., Haase, N., Golic, M., Wa Yung, H., Huppertz, B., Cartwright, J., Whitley, G., Johnsen, G., Levi, G., Isbruch, A., Schulz, H., Luft, F., Mueller, D., Staff, A., Hurst, L.D.*, Dechend, R.*, Izsvák, Z.* (2017) Disturbed placental Imprinting in Preeclampsia leads to altered expression of DLX5, a Human-specific early Trophoblast marker. Circulation 136, 1824-1839 doi:10.1161/CIRCULATIONAHA.117.028110 *co-corresponding authors. Nature Reviews Nephrology Research highlight here.
Abrahams, L. and Hurst, L.D. (2017) Adenine enrichment of the fourth CDS residue in bacterial genes is consistent with error proofing for +1 frameshifts. Molecular Biology and Evolution 34 3064-3080
Link, V., Aguilar-Gómez, D., Ramírez, C., Hurst, L.D. and Cortez, D. (2017) Male mutation bias is the main force shaping chromosomal substitution rates in monotreme mammals. Genome Biology and Evolution 9 2198-2210
Römer, C., Singh, M., Hurst, L.D. and Izsvák, Z. (2017) How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency. Current Opinions in Virology 25, 49-58
Mead, R, Hejmadi, M. and Hurst, L.D. (2017) Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance. Public Library of Science, Biology 15(5): e2002255. https://doi.org/10.1371/journal.pbio.2002255 (The Conversation article here)
Savisaar, R. and Hurst, L.D. (2017) Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution. Molecular Biology and Evolution 34 1110-1126
Savisaar, R. and Hurst, L.D. (2017) Estimating the prevalence of functional exonic splice regulatory information. Human Genetics 136 1059-1078 doi:10.1007/s00439-017-1798-3
Thorpe, H.A., Bayliss, S.C., Hurst, L.D. and Feil, E.J. (2017) Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species using whole genome sequence data. Genetics 206 363-376 (highlight article here)
Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie,, C., Pastor,, M., Sebe,, A, Miskey,, C., Hurst, L.D., Diarra, S., Kropp, M., Walter,, P., Scherman, D., Ivics, Z., Izsvák, Z., , Johnen, S. on behalf of the TargetAMD consortium (2017) Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids. Molecular Therapy - Nucleic Acids 6 302-314
Casey, R., Ascher, D., Rattenberry, E., Izatt, L., Andrews, K., Park, S., Simpson, H., Challis, B., Bulusu, V., Lalloo, F., Pires, D., West, H., Clarke, G., Smith, P., Whitworth, J., Papathomas, T., Taniere, P., Savisaar, R., Hurst, L.D., Woodward, E., Maher, E. (2017) SDHA related tumorigenesis: A New Case Series and Literature Review for Variant interpretation and Pathogenicity. Molecular Genetics & Genomic Medicine 5 237-250 https://doi.org/10.1002/mgg3.279
2016
Liu, H., Jia, Y., Sun, X., Tian, D. Hurst, L.D.* and Yang, S.* (2016) Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and approximate rate constancy in insects. Molecular Biology and Evolution 34 119-130 *co-corresponding authors.
Xie, Z., Wang, L, Wang, L., Wang, Z., Lu, Z. Tian, D., Yang, S. and Hurst, L.D. (2016) Mutation rate analysis via parent-progeny sequencing of the perennial peach I. A low rate in woody perenials and a higher mutagenicity in hybrids. Proc. R. Soc. Lond., B 283 20161016
Wang, L., Zhang, Y., Qin, C., Tian, D., Yang, S. and Hurst, L.D. (2016) Mutation rate analysis via parent-progeny sequencing of the perennial peach II. No evidence for recombination-associated mutation. Proc. R. Soc. Lond., B 283 20161785
McLysaght, A. and Hurst. L.D. (2016) Open questions in the study of de novo genes: what, how, why. Nature Reviews Genetics 17 567-578
Savisaar, R. and Hurst, L.D. (2016) Purifying selection on exonic splice enhancers in intronless genes. Molecular Biology and Evolution 33 1396-1418
Wu, X. and Hurst, L.D. (2016) Determinants of the usage of splice-associated cis-motifs predicts the distribution of human pathogenic SNPs. Molecular Biology and Evolution 33 518-529. (for Nature Reviews Genetics Research Highlight see here)
Wang, J., Singh, M., Sun, C. Besser, D., Prigione, A., Ivics, Z., Hurst, L.D.* and Izsvák, Z.* (2016) Isolation and cultivation of naive-like human pluripotent stem cells based on LTR7/HERVH expression. Nature Protocols 11 327-346 *co-corresponding authors. (for Cover illustration, see here)
2015
Izsvak, Z., Wang, J., Singh, M., Mager, D.L. and Hurst, L.D. (2015) Pluripotency and the endogenous retrovirus HERVH: conflict or serendipity? BioEssays 38 109-117 (Review)
Hurst, L.D., Ghanbarian A.T., Forrest, A.R.R., FANTOM Consortium, Huminiecki, L. (2015) The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. Public Library of Science, Biology 13 e1002315
Yang, S., Wang, L, Huang, J., Zhang, X., Uyan, Y., Chen, J-Q, Hurst, L.D.* and Tian, D.* (2015) Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature 523 463-467 *co-corresponding authors (for News and Views see here)
Wu, X. and Hurst, L.D. (2015) Why selection might be stronger when populations are small: intron size and density predict within and between-species usage of exonic splice associated cis-motifs. Molecular Biology and Evolution 32 1847-186!
Ghanbarian, A.T. and Hurst, L.D. (2015) Neighboring genes show correlated evolution in gene expression. Molecular Biology and Evolution 32 1748-1766
Sealey, K.L., Harris, S.R., Fry, N.K., Hurst, L.D., Gorringe, A.R., Parkhill, J. and Preston, A. (2015) Genomic analysis of isolates from the UK 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving. Journal of Infectious Diseases (in press) (Editor’s choice and Major Article)
Liu, H, Zhang, X., Huang, J., Chen, J-Q, Tian, D., Hurst, L.D.* Yang, S.* (2015) Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee. Genome Biology 16 15 *co-corresponding authors
2014
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D.*, and Izsvák, Z.* (2014) Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells. Nature 516 405-409 *co-corresponding authors
Jiang, C., Mithani, A, Belfield, E.J., Mott, R., Hurst, L.D. and Harberd, N.P. (2014) Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations. Genome Research 24 1821-1829
Schueler, A., Ghanbarian, A.T. and Hurst, L.D. (2014) Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs. Molecular Biology and Evolution 31 3164-3183
Hurst, L.D., Sachenkova, O., Daub, C., Forrest, A.R.R. the FANTOM consortium, Huminiecki, L. (2014) A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators. Genome Biology 15 413
Laabei M., Recker M., Rudkin J.K., Aldeljawi M., Gulay Z., Sloan T.J., Williams P., Endres J.L., Bayles K.W., Fey P.D., Yajjala V.K., Widhelm T., Hawkins E., Lewis K., Parfett S., Scowen L., Peacock S.J., Holden M., Wilson D., Read T.D., van den Elsen J., Priest N.K., Feil E.J., Hurst L.D., Josefsson E., Massey R.C. (2014). Predicting the virulence of MRSA from its genome sequence. Genome Research 24 839-849 doi: 10.1101/gr.165415.113
Yin, S., Yang, J., Lin, B., Deng, W., Zhang, Y., Yi, X., Shi, Y., Tao, Y., Cai, J., Wu, C. I., Zhao, G., Hurst, L. D., Zhang, J., Hu, L., Kong, X., 2014. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Scientific Reports 4, 6036
Charneski, C.A. and Hurst, L.D. (2014) Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp. Molecular Biology and Evolution 31 70-84
2013
Cáceres, E.F and Hurst, L.D. (2013) The evolution, impact and properties of exonic splice enhancers. Genome Biology 14 R143
Zhang, Y., Castillo-Morales, A., Jiang, M., Zhu, Y., Hu, L., Urrutia, A.O., Kong, X. and Hurst, L.D. (2013) Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Molecular Biology and Evolution 30 2588-2601 (MBE News story here; erratum here)
Wu, X., Tronholm, A.,Fernández Cáceres, E., Tovar-Corona, J.M., Chen, L., Urrutia, A.O., Hurst, L.D. (2013) Evidence for deep phylogenetic conservation of exonic splice-related contraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans. Genome Biology and Evolution 5 1731-1745
Maharjan, R., Nilsson, S.,Sung, J., Beardmore, R., Haynes, K., Hurst, L.D., Ferenci, T., Gudelj, I. (2013) The form of a trade-off determines the response to competition. Ecology Letters 16 1267-1276
Liu, Y., Zhang, L., Xu, S., Hu, L., Hurst, L.D. and Kong, X. (2013) Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham Heart Study. Scientific Reports 3 2147
Charneski, C.A. and Hurst, L.D. (2013) Positively charged residues are the major determinants of ribosomal velocity. Public Library of Science, Biology 11 e1001508
Woods, S., Coghlan, A., Rivers, D., Warnecke, T.. Jeffries, S.J., Kwon, T., Rogers, A., Hurst, L.D*. and Ahringer, J. (2013) Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses. Public Library of Science, Genetics 9(5): e1003330 *co-corresponding author
2012
Yang, S., Yuan, Y, Wang, L. Li, J., Wang, W., Liu, H., Chen, J-O, Hurst, L.D.* and Tian, D. (2012) Great majority of recombination events in Arabidopsis are gene conversion events. Proceedings of the National Academy of Sciences, USA 109 20992- 20997 *co-corresponding author
Fehér, T., Bogos, B., Méhi, O., Fekete, G., Csörgő, B., Kovács, K., Pósfai, G., Papp, B., Hurst, L.D. and Pál, C. (2012) Competition between transposable elements and mutator genes in bacteria. Molecular Biology and Evolution 10 3153-3159
He, C, Li, Z., Chen, P., Huang, H. Hurst, L.D.* and Chen, J. (2012) Young intragenic miRNAs are less co-expressed with host genes than old ones: implications of miRNA host gene coevolution. Nucleic Acids Research 40 4002-4012 *co-last author
Weber, C.C., Pink, C.J. and Hurst, L.D. (2012) Late replicating domains have higher divergence and diversity in Drosophila melanogaster. Molecular Biology and Evolution 29 873-882
Webster, M.T. and Hurst, L.D. (2012) Direct and indirect consequences of meiotic recombination: implications for genome evolution. Trends in Genetics 28 101-109
2011
Warnecke, T. and Hurst, L.D. (2011) Error prevention and mitigation as forces in the evolution of genes and genomes. Nature Reviews Genetics 12 875-881
Charneski, C. A., Honti, F., Bryant, J.M., Hurst L.D.* and Feil, E. J. (2011) Atypical AT skew in Firmicute genomes results from selection and not from mutation. Public Library of Science, Genetics 7 e1002283 *co-last author
Pink, C.J. and Hurst, L.D. (2011) Late replicating domains are highly recombining in females but have low male recombination rates: Implications for isochore evolution. Public Library of Science, One 6 e24480
Nahorski, M.S., Reiman, A., Lim, D.H.K, Nookala, R., Seabra, L., Lu, X., Fenton, J., Boora, U., Blundell, T.L., Latif, F., Hurst, L.D., Maher, E.R. (2011) Birt Hogg-Dubé syndrome associated FLCN mutations disrupt protein stability. Human Mutation 8 921-929
Beardmore, R., Gudelj, I., Lipson, D.A. and Hurst, L.D. (2011) Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature 472 342-346
Wang, G-Z, Lercher, M.J. and Hurst, L.D. (2011) Transcriptional coupling of neighbouring genes and gene expression noise: evidence that gene orientation and non-coding transcripts are modulators of noise. Genome Biology and Evolution 3 320-331
Weber, C.C. and Hurst, L.D. (2011) Support for multiple classes of expression cluster in Drosophila melanogaster, but no evidence for gene order conservation. Genome Biology 12 R23
Garfield, A.S., Cowley, M., Smith, F.M., Moorwood, K., Stewart-Cox, J.E., Gilroy, K., Baker, S., Xia, J., Dalley, J.W., Hurst, L.D., Wilkinson, L.S., Isles, A.R., Ward, A. (2011) Distinct physiological and behavioural functions for the parental alleles of the imprinted Grb10 gene. Nature 469 534-538
2010
Zhang, Z. Zhou, L., Hu, L., Zhu,Y., Xu, H., Liu, Y, Chen,X., Yi, X., Kong, X., Hurst, L.D. (2010) Multiple sequence-related features act in concert to prevent translation of nonsense-mediated mRNA decay targets. Molecular Systems Biology 6 442
MacLean, C, Fuentes-Hernandez, A., Greig, D. Hurst, L.D.* and Gudelj, I. (2010) A mixture of “cheats” and “co-operators” can enable maximal group benefit. Public Library of Science, Biology 8 e1000486 *co-last author
Weber, C.C. and Hurst, L.D. (2010) Intronic AT skew is a defendable proxy for germ-line transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster. Journal of Molecular Evolution 71 415-426
Warnecke, T, Huang, Y., Przytycka, T.M. and Hurst, L.D. (2010) Unique cost dynamics elucidate the role of frame-shifting errors in promoting translational robustness. Genome Biology and Evolution 2 636-645
McDonald, L.A., Gerrelli, D., Hurst, L.D. and Tickle, C. (2010) Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos. Journal of Anatomy 216 683-691
Pink, C.J. and Hurst, L.D. (2010) Timing of replication is a determinant of neutral substitution rates but does not explain slow Y chromosome evolution in rodents. Molecular Biology and Evolution 27 1077-1086
Warnecke, T and Hurst, L.D. (2010) GroEL dependency affects codon usage - support for a critical role of misfolding in gene evolution. Molecular Systems Biology 6 340 (MSB News and Views here)
Charalambous, M., Cowley, M., Googehan, F., Smith, F. M., Radford, E., Marlow, B.P., Graham, C.F. Hurst, L.D. and Ward, A. (2010) Maternally-inherited Grb10 reduces placental size and efficiency. Developmental Biology 337 1-8
2009
Neçsulea, A, Sémon, M, Duret, L. and Hurst, L.D. (2009) Monoallelic expression and tissue specificity are associated with high crossing-over rates. Trends in Genetics 25 519-522
Weber, C.C. and Hurst, L.D. (2009) Protein rates of evolution are predicted by double-strand break events, independent of crossing over rates. Genome Biology and Evolution 1 340-349
Warnecke, T., Wang, G-Z, Lercher, M.J. and Hurst, L.D. (2009) Does negative autoregulation increase gene duplicability? BMC Evolutionary Biology 9 R193
Yin, S., Wang, P., Zheng, H., Hu, L. Hurst, L.D.* and Kong, X. (2009) Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals. Genome Biology 10 R74 *co-last author
Warnecke, T. Weber, C.C. and Hurst, L.D. (2009) Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence. Biochemical Transactions 37 756-761
Pink, C.J., Swaminathan, S.K., Dunham, I., Rogers, J., Ward, A. Hurst, L.D. (2009) Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates. Genome Biology and Evolution 1 13-22
Kovács, K., Hurst, L.D.* and Papp, B. (2009) Stochasticity in protein levels drives colinearity of gene order in metabolic operons of E. coli. Public Library of Science Biology 7 e1000115 *co-last author
Zhang, Z., Xin, D., Wang, P., Zhou, L, Hu, L., Kong, X. and Hurst, L.D. (2009) Noisy splicing, more than regulated translation, explains why some exons are subject to nonsense-mediated decay. BMC Biology 7 23
Hurst, L.D. (2009) Genetics and the understanding of selection. Nature Reviews Genetics 10 83-93 (Review)
2008
Warnecke, T., Batada, N. and Hurst, L.D. (2008) The impact of the nucleosome code on coding sequence evolution in yeasts. Public Library of Science, Genetics 4 e1000250
Wang, P., Yin, S., Zhang Z., Xin, D., Hu, L., Kong, X., and Hurst, L.D. (2008) Evidence for common short natural trans sense–antisense pairing between transcripts from protein coding genes. Genome Biology 9 R169
Forde, S.E., Beardmore, R.E., Gudelj, I, Arkin, S.S., Thompson, J.N. and Hurst, L.D. (2008) Understanding the limits to generalisability of experimental evolutionary models. Nature 455 220-224
Reuter, M. Engelstadter, J., Fontanillas, P. and Hurst, L.D. (2008) A test of the null model for 5’ UTR evolution based on GC-content. Molecular Biology and Evolution 25 801-804
Lopes, S.S., Yang, X., Mueller, J., Carney, T.J., McAdow, A.R., Rauch, G.-J,. Jacoby, A.S., Hurst, L.D., Delfino-Machin, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., Kelsh, R.N. (2008) Leukocyte Tyrosine Kinase functions in pigment cell development. Public Library of Science, Genetics 4 e1000026
Urrutia, A.O. Ocana, L.B. and Hurst, L.D. (2008) Do Alu repeats shape the primate transcriptome? Genome Biology 9 R25
Warnecke, T, Parmley, J.L. and Hurst, L.D. (2008) Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes. Genome Biology 9 R29
Champion de Crespigny, F., Hurst, L.D. and Wedell, N. (2008) Do Wolbachia associated incompatibilities promote polyandry? Evolution 62 107-122
2007
Poyatos, J. and Hurst, L.D. (2007) Determinants of gene order conservation in yeast. Genome Biology 8 R233
Warnecke, T. and Hurst, L.D. (2007) Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster. Molecular Biology and Evolution 24 2755-2762
Batada, N.N. and Hurst, L.D. (2007) Evolution of chromosome organization driven by selection for reduced gene expression noise. Nature Genetics 39 945-949
Batada, N.N., Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, BJ, Hurst, L.D*. and Tyers, M. (2007) Still stratus not altocumulus: Further evidence against the date/party hub distinction. Public Library of Science Biology 5 e154 *co-last author
Batada, N.N. Urrutia, A.O. and Hurst, L.D. (2007) Chromatin remodeling is a major source of co-expression of linked genes in yeast. Trends in Genetics 23 480-484
Parmley, J.L. and Hurst, L.D. (2007) Exonic splicing regulatory elements skew synonymous codon usage near intron exon boundaries in mammals. Molecular Biology and Evolution 24 1600-1603
Parmley, J.L. and Hurst, L.D. (2007) How common are intragene windows with KA>KS owing to purifying selection on synonymous mutations? Journal of Molecular Evolution 64 646-655
Parmley, J.L., Urrutia, A.O., Potrzebowski, L, Kaessmann, H. and Hurst, L.D. (2007) Splicing and the evolution of proteins in mammals. Public Library of Science Biology 5, 343-353 (e14)
2006
Hurst, L.D., Feil, E.J. and Rocha, E.P.C. (2006) Causes of trends in amino-acid gain and loss. Nature 442 E11-E12. supplement
Simoes, B., Conceicao, N., Viegas, C.S., Pinto, J.P., Gavaia, P.J., Hurst, L.D., Kelsh, R.N. and Cancela, M.L. (2006) Identification of a Promoter Element within the Zebrafish colXalpha1 Gene Responsive to Runx2 Isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcified Tissue International 79 230-244.
Batada, N.N., Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, BJ, Hurst, L.D*. and Tyers, M. (2006) Stratus not altocumulus: a new view of the yeast protein interaction network. Public Library of Science Biology 4 1720-1731 *co-last author
Sun, M, Hurst, L.D., Carmichael, G.G. and Chen, J. (2006) Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship to organismic complexity. Genome Research 16 922-933
Batada, N.N., Hurst, L.D. and Tyers, M. (2006) Evolutionary and physiological importance of hub proteins. Public Library of Science, Computational Biology 2 e88
Poyatos, J. and Hurst, L.D. (2006) Is optimal gene order impossible? Trends in Genetics 22 420-423
Hurst, L.D. (2006) Preliminary assessment of the impact of microRNA mediated regulation on coding sequence evolution in mammals. Journal of Molecular Evolution 63 174-182
Lercher, M.J. and Hurst, L.D. (2006) Evidence that co-expressed genes cluster but are not regularly spaced. Journal of Molecular Biology 359 825-831
Pál, C., Papp, B., Lercher, M.J., Csermely, P., Oliver, S.G. and Hurst, L.D. (2006) Chance and necessity in the evolution of minimal metabolic networks. Nature 440 667-670
Parmley, J.L., Chamary, J-V. and Hurst, L.D. (2006) Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers. Molecular Biology and Evolution 23 301-309
Rocha, E. P., Smith, J. M., Hurst, L.D., Holden, M. T., Cooper, J. E., Smith, N. H. and Feil, E. J. 2006 Comparisons of dN/dS are time dependent for closely related bacterial genomes. Journal of Theoretical Biology 239, 226-35.
Chamary, J-V., Parmley, J.L., and Hurst, L.D. (2006) Hearing silence: non-neutral evolution at synonymous sites in mammals. Nature Reviews Genetics 7 98-108 (Review)
2005
Hurst, L.D. and Lercher, M.J. (2005) Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome. BMC Evolutionary Biology 6 R62
Sun, M., Hurst, L.D., Carmichael, G.G. and Chen, J. (2005) Evidence for a preferential targeting of 3' UTRs by cis-encoded natural antisense transcripts. Nucleic Acids Research 33 5333-5543
Chen, J., Sun, M., Rowley, J.D. and Hurst, L.D. (2005) The small introns of antisense genes are better explained by selection for rapid transcription than by “genomic design”. Genetics 171 2151-2155
Chamary, J-V. and Hurst, L.D. (2005) Evidence for selection on synonymous mutations for stable mRNA secondary structure in mammals. Genome Biology 6 R75
Seoighe, C, Gehring, C and Hurst, L.D. (2005) Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. Public Library of Science, Genetics 1 e13
Pinto, J.P., Conceicao, N.M., Viegas, C.S., Leite, R.B., Hurst, L.D., Kelsh, R.N., and Cancela, M.L. (2005). Identification of a new pebp2A2 isoform from Zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. Journal of Bone and Mineral Research 20 1440-1453
Gissen, P., Johnson, C.A., Gentle, D. Hurst, L.D., Doherty, A. O’Kane, C.J., Kelly, D.A., Maher, E.A. (2005) Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Human Molecular Genetics 14 1261-1270
Chen, J., Sun, M., Hurst, L.D., Carmichael, G.G. & Rowley, J.D. (2005) Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts. Trends in Genetics 21 326-329
Chamary, J-V. and Hurst, L.D. (2005) Biased codon usage near intron-exon junctions: selection on splice enhancers, splice site recognition or something else? Trends in Genetics 21 256-259
Chen, J., Sun, M., Hurst, L.D., Carmichael, G.G. & Rowley, J.D. (2005) Human antisense genes have unusually short introns: evidence for selection for rapid transcription. Trends in Genetics 21 203-207
Ruvinsky, A., Eskesen, S., Eskesen, F. and Hurst, L.D. (2005) Can codon usage bias explain intron phase distribution and exon symmetry? Journal of Molecular Evolution 60 99-104
2004
Poyatos, J.F. and Hurst, L.D. (2004) How biologically relevant are interaction-based modules in protein networks? Genome Biology 5 R93
Holden M. T., Feil E. J., Lindsay J. A., Peacock S. J., Day N. P., Enright M. C., Foster T. J., Moore C. E., Hurst, L.D. et. al. (2004). Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proceedings of the National Academy of Sciences, USA 101 9786-9791
Papp, B., Pál, C., and Hurst, L.D. (2004) Metabolic network analysis of causes and evolution of enzyme dispensibility in yeast. Nature 429 661-664
Lercher, M.J., Chamary, J-V. and Hurst, L.D. (2004) Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile. Genome Research 14 1002-1013
Pál, C., and Hurst, L.D. (2004) Evidence against the selfish operon hypothesis. Trends in Genetics 20 232-234
Chamary, J-V and Hurst, L.D. (2004) Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage. Molecular Biology and Evolution 21 1014-1023
Hurst, L.D., Pál, C. and Lercher, M.J. (2004) The evolutionary dynamics of eukaryotic gene order. Nature Reviews Genetics 5 299-310 (Review)
2003
Lercher, M.J. and Hurst, L.D. (2003) Imprinted chromosomal regions of the human genome have unusually high recombination rates. Genetics 165 1629-1632
Urrutia, A.O. and Hurst, L.D. (2003) The signature of selection mediated by expression on human genes. Genome Research 13 2260-2264
Lercher, M.J., Urrutia, A.O. Pavlícek, A. and Hurst, L.D. (2003) A unification of mosaic structures in the human genome. Human Molecular Genetics 12 2411-2415
Papp, B., Pál, C., and Hurst, L.D. (2003) Evolution of cis-regulatory elements in duplicate genes in yeast. Trends in Genetics 19 417-422
Papp, B., Pál, C., and Hurst, L.D. (2003) Dosage sensitivity and the evolution of gene families in yeast. Nature 424 194-197
Lercher, M.J. Urrutia, A.O. and Hurst, L.D. (2003) Evidence that the human X chromosome is enriched for male specific but not female specific genes. Molecular Biology and Evolution 20 1113-1116
Charalambous, M, Ward, A and Hurst, L.D. (2003) Evidence for a priming effect on maternal resource allocation: implications for inter-brood competition. Proceedings of the Royal Society, London, Biology Letters DOI 10.1098/rsbl.2003.0028. 270 S100-S103
Pál, C. and Hurst, L.D. (2003) Evidence for co-evolution of gene order and recombination rate. Nature Genetics 33 392 - 395
Lercher, M.J., Blumenthal, T. and Hurst, L.D. (2003) Co-expression of neighbouring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Research 13 238-243
Pál, C., Papp, B. and Hurst, L.D. (2003) Rate of evolution and gene dispensability. Nature 421 496-497
2002
Lercher, M.J., Smith, N., Eyre-Walker, A. and Hurst, L.D. (2002) The evolution of isochores: evidence from SNP frequency distributions. Genetics 162 1805-1810
Lercher, M.J. and Hurst, L.D. (2002) Can mutation or fixation biases explain the allele frequency distribution of human SNPs? Gene 300 53-58
Hurst, L.D., Williams, E.J.B. and Pál, C. (2002) Natural selection promotes the conservation of linkage of co-expressed genes. Trends in Genetics 18 604-606
Williams, E.J.B. and Hurst, L.D. (2002) Is the synonymous substitution rate in mammals gene-specific? Molecular Biology and Evolution 19 1395-1398
Lercher, M.J. and Hurst, L.D. (2002) Human SNP variability and mutation rate are higher in regions of high recombination. Trends in Genetics 18 337-340
Lercher, M.J., Urrutia, A.O. and Hurst, L.D. (2002) Clustering of house keeping genes provides a unified model of gene order in the human genome. Nature Genetics 31 180-183
Williams, E.J.B. and Hurst, L.D. (2002) Clustering of tissue specific genes underlies much of the similarity in rates of protein evolution of linked genes. Journal of Molecular Evolution 54 511-518
2001
Urrutia, A.O. and Hurst, L.D. (2001) Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection. Genetics 159 1191-1199
Pál, C., Papp, B. and Hurst, L.D. (2001) Does the recombination rate affect the efficiency of purifying selection? The yeast genome provides a partial answer. Molecular Biology and Evolution 18 2323-2326
Lercher, M.J., Williams, E.J.B., and Hurst. L.D. (2001) Local similarity in evolutionary rates extends over whole chromosomes in human-rodent and mouse-rat comparisons: implications for understanding the mechanistic basis of the male mutation bias. Molecular Biology and Evolution 18 2032-2039
Randerson, J., Moreau, J., Rigaud, T. and Hurst, L.D. (2001) Understanding the distribution and effects of Wolbachia: the co-existence of cytoplasmic incompatibility and feminization. Selection 2 237-248
Randerson, J.P. and Hurst, L.D. (2001) The uncertain evolution of the sexes. Trends in Ecology and Evolution 16, 571-579 (Review)
Veitia, R.A. and Hurst, L.D. (2001) Insect orthologues of ERG28/C14orf1 under selection pressure: a link with ecdysteroid metabolism? Journal of Genetics 80 17-21
Eyre Walker, A and Hurst, L.D. (2001) The evolution of isochores. Nature Reviews Genetics 2 549-555 (Review)
Pál, C, Papp, B and Hurst, L.D. (2001) Highly expressed genes in yeast evolve slowly. Genetics 158 927-931
Duret, L and Hurst, L.D. (2001) The elevated G and C content at exonic third sites is not evidence against neutralist models of isochore evolution. Molecular Biology and Evolution 18 757-762
Randerson, J.P. and Hurst, L.D. (2001) A comparative test of a theory of the evolution of anisogamy. Proceedings of the Royal Society, London Series B 268 879-884
Hurst, L.D. and Merchant, A. R. (2001) High guanine-cytosine content is not an adaptation to high temperature: a comparative analysis amongst prokaryotes. Proceedings of the Royal Society, London Series B 268 493-497
Hurst, L.D. and Pál, C. (2001) Evidence for purifying selection on silent sites in BRCA1. Trends in Genetics 17 62-65
2000
Hurst, L.D. and Williams, E.J.B. (2000) Covariation of GC content and the silent site substitution rate in rodents: implications for methodology and for the evolution of isochores. Gene 261 107-114
Williams, E.J.B. and Hurst, L.D. (2000) The proteins of linked genes evolve at similar rates. Nature 407 900-903
Hurst, L.D. and Randerson, J.P. (2000) Dosage, deletions and dominance: the evolution of gene expression. Journal of theoretical Biology 205 641-647
Williams, E.J.B., Pál, C and Hurst, L.D. (2000) The molecular evolution of signal peptides. Gene 253 313-322
Pál, C and Hurst, L.D. (2000) The evolution of gene number: are heritable and non-heritable errors equally important? Heredity 84 393-400
Randerson, J.P., Jiggins, F. and Hurst, L.D. (2000) Male killing can select for male mate choice: a novel solution to the paradox of the lek. Proceedings of the Royal Society, London Series B. 267 867-874
Woodward, E.R. Buchberger, A., Clifford, S.C., Hurst, L.D., Affara, N.A. and Maher, E.R. (2000) Comparative Sequence Analysis of The VHL Tumour Suppressor Gene. Genomics 65 253-265
Hurst, L.D. and Randerson, J.P. (2000) Transitions in the evolution of meiosis. Journal of Evolutionary Biology 13 466-479
Freeland, S., Knight, R.D., Landweber, L.F. and Hurst, L.D. (2000) Early fixation of an optimal genetic code. Molecular Biology and Evolution 17 511-518
Randerson, J.P., Smith, N.G.C. and Hurst, L.D. (2000) The evolutionary dynamics of male-killers and their hosts. Heredity 84 152-160 appendix
1999
Smith, N.G.C. and Hurst, L.D. (1999) The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents. Genetics 153 1395-1402
Randerson, J. P. and Hurst, L.D. (1999) Small sperm, uniparental inheritance and selfish cytoplasmic elements: A comparison of two models. Journal of Evolutionary Biology 12 1110-1124.
Hurst, L.D. (1999) The evolution of genomic anatomy. Trends in Ecology and Evolution 14 108-112 (Review)
Hurst, L.D. (1999) Is multiple paternity necessary for the evolution of genomic imprinting? Genetics 153 509-512
Hurst, L.D. and Smith, N.G.C. (1999) Do essential genes evolve slowly? Current Biology 9 747-750 appendix
Smith, N. G.C. and Hurst, L.D. (1999) The causes of synonymous rate variation in the rodent genome: can substitution rates be used to estimate the sex bias in mutation rate? Genetics 152 661-673
1998
Hurst, L.D. and McVean, G.T. (1998) Do we understand the evolution of genomic imprinting? Current Opinion in Genetics and Development 8 701-708 (Review)
Freeland, S. and Hurst, L.D. (1998) Load minimization of the genetic code: history does not explain the pattern. Proceedings of the Royal Society, London Series B 265 2111-2119
Smith, N.G.C. and Hurst, L.D. (1998) The molecular evolution of an imprinted gene: repeatability of patterns of molecular evolution in the insulin-like growth factor type 2 receptor. Genetics 150 823-833
Partridge, L. and Hurst, L.D. (1998) Sex and Conflict. Science 281 2003 - 2008 (Review)
Hurst, L.D. and Ellegren, H.A. (1998) Sex biases in the mutation rate. Trends in Genetics 14 446-452 (Review)
Smith, N.G.C. and Hurst, L.D. (1998) Sensitivity of patterns of molecular evolution to alterations in methodology: a critique of Hughes and Yeager. Journal of Molecular Evolution 47 493-500
Freeland, S. and Hurst, L.D. (1998) The genetic code is one in a million. Journal of Molecular Evolution 47 238-248
Hurst, L.D. and Smith, N.G.C. (1998) The evolution of concerted evolution. Proceedings of the Royal Society, London Series B 265 121-127
1997
McVean, G.T. and Hurst, L.D. (1997) Evidence for a selectively favourable reduction in the mutation rate of the X chromosome. Nature 386 388-392
Hurst, L.D. and McVean, G.T. (1997) Growth effects of uniparental disomies and the conflict theory of genomic imprinting. Trends in Genetics 13 436-443
McVean, G.T and Hurst, L.D. (1997) Molecular evolution of imprinted genes: no evidence for antagonistic coevolution. Proceedings of the Royal Society, London Series B 264 739-746
1996
Hurst, L.D., Atlan, A. and Bengtsson, B. O. (1996) Genetic conflict. The Quarterly Review of Biology 71 317-364 (Review)
Hurst. L.D. (1996) Why are there only two sexes? Proceedings of the Royal Society, London Series B 263 415-422
McVean, G.T. and Hurst, L.D. (1996) Genetic conflict and the paradox of sex determination: three paths to the evolution of female intersexuality in a mammal. Journal of theoretical Biology 179 199-211
Reed, J.N. and Hurst, L.D. (1996) Dynamic analysis of the evolution of a novel genetic system: the evolution of ciliate meiosis. Journal of theoretical Biology 178 355-368
Hurst, L.D., McVean, G.T., and Moore, T. (1996) Imprinted genes have few and small introns. Nature Genetics 12 234-237
Hurst, L.D. and Peck, J.R. (1996) Recent advances in the understanding of the evolution and maintenance of sex. Trends in Ecology and Evolution 11 46-52 (Review)
Hurst, L.D. (1996) Further evidence consistent with Stellate's involvement in meiotic drive. Genetics 142 641-643
Hurst, L.D. and McVean, G.T. (1996) Clade selection, reversible evolution and the persistence of selfish elements: the evolutionary dynamics of cytoplasmic incompatibility. Proceedings of the Royal Society, London Series B 263 97-104
1995
Moore, T., Hurst, L.D., Reik, W. (1995) Genetic conflict and the evolution of mammalian X chromosome inactivation. Developmental Genetics 17 206-211
Hurst, L.D. (1995) Selfish genetic elements and their role in evolution: the evolution of sex and some of what that entails. Philosophical Transactions of the Royal Society, London Series B. 349 321-332
1994
Hurst, L.D. (1994) Cytoplasmic genetics under inbreeding and outbreeding. Proceedings of the Royal Society, London Series B 258 287-298
Hurst, L.D. (1994) Embryonic growth and the evolution of the mammalian Y chromosome. I. The Y as an attractor for selfish growth factors. Heredity 73 223-232
Hurst, L.D. (1994) Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of Y-linked selfish growth factors may explain escape from X-inactivation and rapid evolution of Sry. Heredity 73 233-243
Crampton, W.G.R. and Hurst, L.D. (1994) True kin recognition, in the form of somatic incompatibility, has multiple independent origins. Animal Behaviour 47 230-234
1993
Hurst, L.D. (1993) A model for the mechanism of transmission ratio distortion and for t-associated hybrid sterility. Proceedings of the Royal Society, London Series B 253 83-91
Hurst, L.D. (1993) The incidences, mechanisms and evolution of cytoplasmic sex ratio distorters in animals. Biological Reviews 68 121-193 (Review)
Pomiankowski, A. and Hurst, L.D. (1993) Genomic conflicts underlying Haldane's rule. Genetics 133 425-432
1992
Hurst. L.D. and Hamilton, W.D. (1992) Cytoplasmic fusion and the nature of sexes. Proceedings of the Royal Society, London Series B 247 189-194
Hurst, G.D.D., Hurst, L.D. and Johnstone, R. (1992) Intra-nuclear conflict and its role in evolution. Trends in Ecology and Evolution 7 373-378 (Review)
Hurst, L.D. (1992) Intra-genomic conflict as an evolutionary force. Proceedings of the Royal Society, London Series B 248 135-140
1991
Hurst, L.D. and Pomiankowski, A. (1991) Causes of sex-ratio bias may account for unisexual sterility in hybrids: a new explanation of Haldane's rule and related phenomena. Genetics 128 841-858
Hurst, L.D. (1991) The evolution of cytoplasmic incompatibility or when spite can be successful. Journal of theoretical Biology 148 269-277
Hurst, L.D. (1991) The incidences and evolution of cytoplasmic male killers. Proceedings of the Royal Society, London Series B 244 91-99
Haig, D. and Hurst, L.D. (1991) A quantitative measure of error-minimization in the genetic code. Journal of Molecular Evolution 33 412-417
1990
Hurst, L.D. (1990) Parasite diversity and the evolution of diploidy, multicellularity and anisogamy. Journal of theoretical Biology 144 429-443
SHORT COMMUNICATIONS
Hurst, L.D. (2013) Open questions: A logic (or lack thereof) of genome organization. BMC Biology 11 58 (invited comment)
Randerson, J.P and Hurst, L.D. (2002) Survival and anisogamy. Trends in Ecology and Evolution 17 358
Hurst, L.D., Pomiankowski, A. and McVean, G.T. (2000) Peg3 and the conflict hypothesis. Science 287 1167
Hurst, L.D., Brunton, C.F.A. and Smith, N.G.C. (1999) Small introns tend to occur in GC rich regions in some but not all vertebrates. Trends in Genetics 15 437-439
Hurst, L.D. and Smith, N.G.C. (1999) Molecular evolutionary evidence that H19 mRNA is functional. Trends in Genetics 15 134-135
Frank, S.A. and Hurst, L.D. (1996) Mitochondria and male disease. Nature 383 224
McVean, G.T. , Hurst, L.D. and Moore, T. (1996) Genomic evolution in mice and men: imprinted genes have little intronic content. BioEssays 18 773-775
Hurst, G.D.D., Hurst, L.D. and Barrett, J.A. (1995) Meiotic drive and myotonic dystrophy. Nature Genetics 10 132-133
Hurst, L.D. (1994) Invasion test. Nature 369 284
Hurst, L.D. (1993) scat+ is a selfish gene analogous to Medea of Tribolium castaneum. Cell 75 407-408
Hurst, L.D. and Grafen, A. (1993) Unusual mutational mechanisms and evolution. Science 260 1959
Hurst, L.D. and Pomiankowski, A. (1992) Speciation events. Nature 359 781
Hurst, L.D. (1992) Is Stellate a relict meiotic driver? Genetics 130 229-230
Hurst, L.D. and Haig, D. (1991) Prion infection. Nature 351 21
Hurst, L.D. and Nurse, P. (1991) A note on the evolution of meiosis. Journal of theoretical Biology 150 561-563
Hurst, L.D. and Pomiankowski, A. (1991) Maintaining mendelism: might prevention be better than cure? BioEssays 13 489-490
Hurst, L.D. and Ladle, R. (1991) Parasites pervert procreation. Trends in Ecology and Evolution 6 302
BOOK CHAPTERS AND CONTRIBUTIONS
Buchan, L.L., Hejmadi, M.V. and Hurst, L.D. (2019) Evidence for the success of a quantitative assessment instrument for teaching evolution in primary schools in England. In: Evolution Education re-considered: understanding what works. Edited by Harms, U and Reiss, M.J. Springer , Cham Switzerland pp 21-40
Hurst, L.D. and Pál, C. (2007) How and why are most genes dispensable? In: Evolutionary Genomics and Proteomics (Ed. Pomiankowski, A. and Pagel, M.). Sinauer Associates
Hurst, L.D. (2005) Sex, sexes and selfish elements. In: The Narrow Roads of Gene Land, Volume 3, Last Words. (Ed. Ridley, M.). Oxford University Press pp 89-112
Urrutia, A.O. and Hurst, L.D. (2005) Identifying selection signatures in mammalian genes through the analysis of patterns of gene expression. In: SAGE: Current Technologies and Applications. (Ed. Wang, S.M.) Horizon Scientific Press pp 239-264
Pál, C. and Hurst, L.D. (2004) Epigenetic inheritance and evolutionary adaptation. In: Organelles, genomes and eukaryote phylogeny: an evolutionary synthesis in the age of genomics. (Ed Hirt, R. P. and Horner, D. S.) CRC Press pp 353-370
Hurst, L.D. (2003) Mutation rate: sex biases in. In: Encyclopedia of the Human Genome (Ed. D Cooper). Macmillan
Hurst, L.D. (2002) Sexes and mating types. In: Encylopedia of Evolution. (Ed. M. Pagel). Oxford University Press
Hurst, L.D. (2001) Selfish genes. In: The Encyclopedia of Genetics. (Ed E. Reeve). Fitzroy Dearborn
Hurst, L.D. (1997) Evolutionary theories of genomic imprinting. In: Genomic Imprinting. (Eds. W. Reik and A. Surani). IRL Press pp 211-237
Hurst, G.D.D., Hurst, L.D. and Majerus, M.E.N. (1997) Cytoplasmic sex ratio distorters. In: Influential Passengers (Ed Hoffmann, A, O'Neill, S. and Werren, J). Oxford University Press pp 125-154
Hurst, L.D. (1996) Adaptation and selection of genomic parasites. In: Adaptation. (Eds. M.R. Rose and G.V. Lauder). Academic Press. pp 407-449
Hurst, L.D. (1996) Sexualität als Überlebenschance. In: Planet des Lebens. Verlagsgesellschaft. pp 130-131
Hurst, L.D. (1998) Conflict, Segregation Distortion, Meiotic Drive, Selfish DNA etc. In: The Encyclopaedia of Ecology and Environmental Management. (Ed P. Calow) Blackwell Science ISBN
NATURE - NEWS AND VIEWS
Hurst, L.D. (2011) Molecular Genetics: The sound of silence. Nature 471 582-583
Hurst, L.D. (2009) Evolutionary genomics: A positive becomes a negative. Nature 457 543-544
Hurst, L.D. and Pál, C. (2005) Dissecting dispensability. Nature Genetics 37 214-215
Hurst, L.D. and Ellegren, H. (2002) Mystery of the mutagenic male. Nature 420 365-366
Hurst, L.D. (2001) Sex and the X. Nature 411 149-150
Hurst, L.D. (1998) Peromysci, promiscuity and imprinting. Nature Genetics 20 315-316
Hurst, L.D. and Pomiankowski, A. (1998) The eyes have it. Nature 391 223-224
Hurst, L.D. and Hurst, G.D.D. (1996) Genomic revolutionaries rise up. Nature 384 317-318
Hurst, L.D. and McVean, G.T. (1996) Scandalous symbionts. Nature 381 650-651
Hurst, L.D. (1994) The uncertain origin of introns. Nature 371 381-382
Hurst, L.D. and Hoekstra, R.F. (1994) Shellfish genes kept in line. Nature 368 811-812
Hurst, L.D. (1993) Drunken walk of the diploid. Nature 365 206-207
Pomiankowski, A. and Hurst, L.D. (1993) Siberian mice upset mendel. Nature 363 396-397
Hurst, L.D. and Dawkins, R. (1992) Life in a test-tube. Nature 357 198-199
Hurst, G.D.D., Hurst, L.D. and Majerus, M.E.N. (1992) Selfish genes move sideways. Nature 356 659-660
Hurst, L.D.(1991) Sex, slime and selfish genes. Nature 354 23-24
Hurst, L.D., Godfray, H.C.J. and Harvey, P. (1990) Antibiotics cure asexuality. Nature 346 510-511
SCIENTIFIC JOURNALISM (ACADEMIC)
Hurst, L.D. (2017) It’s easier to get along with quite neighbours. Molecular Systems Biology 13, 943 DOI 10.15252/msb.20177961
Hurst, L.D. (2009) Evolutionary genomics and the reach of selection. Journal of Biology 8 12
Hurst, L.D. and Pal, C. (2009) The hows and whys of dispensability. The Biochemist 31 30-34
Parmely, J.L. and Hurst, L.D. (2007) How do synonymous mutations affect fitness? BioEssays 29 515-519
Hurst, L.D. and Duret, L. (2005) Bioinformatics with a French accent. Genome Biology 6 349
Hurst, L.D. (2002) Detecting recent selection. Trends in Genetics 18 617-618
Hurst, L.D. (2002) The Ka/Ks ratio: diagnosing the form of sequence evolution. Trends in Genetics 18 486-487
Hurst, L.D. (2000) Crossing over a boundary. Trends in Genetics 16 542
Hurst, L.D. (2000) Life without sex. Trends in Genetics 16 338
Hurst, L.D. and Eyre-Walker, A. (2000) Evolutionary genomics: reading the bands. BioEssays 22, 105-107
Pomiankowski, A and Hurst, L.D. (1999) Driving sexual preference. Trends in Ecology and Evolution 14 425-426
Hurst, L.D. and Randerson, J.P.(1999) An eXceptional chromosome. Trends in Genetics 15 383-385
Smith, N.G.C., Knight, R. and Hurst, L.D. (1999) Vertebrate genome evolution: a slow shuffle or a big bang? BioEssays 21 697-703
Freeland, S. J. and Hurst, L.D. (1997) Curious sex ratios and cytoplasmic genes. Resonance 2 68-78
Marrow, P., Johnstone, R.A., Hurst, L.D. (1996) Riding the evolutionary streetcar: where population genetics and game theory meet. Trends in Ecology and Evolution 11 445-446
Hurst, L.D. and McVean, G.T. (1996) A difficult phase for introns-early. Current Biology 6 533-536
Hurst, L.D. (1995) The silence of the genes. Current Biology 5 459-461
Hurst, G.D.D., Hurst, L.D. and Majerus, M.E.N. (1993) Altering sex ratios: the games microbes play. BioEssays 15 695-697
Hurst, L.D. and Vollrath, F. (1992) Sex ratio adjustment in solitary and social spiders. Trends in Ecology and Evolution 7 326-327
Hurst, L.D., Hamilton, W.D. and Ladle, R. (1992) Covert sex. Trends in Ecology and Evolution 7 144-145
Hurst, L.D. (1992) Sociable beetles. Nature 356 111
Hurst, L.D. and Grafen, A. (1990) Sex and flagellation. Trends in Ecology and Evolution 5 419-421
SCIENTIFIC JOURNALISM (POPULAR)
Hurst, L.D. and Huminiecki, L. (2016) Why is the X chromosome so odd? The Conversation.
Chamary, J-V. and Hurst, L.D. (2009) The price of silent mutations. Scientific American 300 (6), 34-41
Hurst, L.D. (2008) What would Darwin have made of the Human Genome Project? Guardian, Feb 9th 2008
Freeland, S. and Hurst, L.D. (2004) Der raffinierte code des lebens. Spektrum der Wissenshaft 07/04 86-93
Freeland, S. and Hurst, L.D. (2004) Evolution encoded. Scientific American 290 84-91
Randerson, J. P. and Hurst, L.D. (2002) Parasitic sex puppeteers. Scientific American 286 56-61
Hurst, L.D. and O'Donnell, I. (1993) Loading the dice. The Economist 7816 105
Ladle, R., Crook, A. and Hurst, L.D. (1992) Honey I ate the kids. New Scientist 1838 17
Hurst, L.D. and May, K. (1991) And only man is vile. The Economist 320 33
Ladle, R., Hurst, L.D. and Johnstone, R. (1991) Cannibals eat their way to an early death. New Scientist 1723 23
