Caggiano Group Webpages
Group InterestsCancer Research at Bath (CR@B)
Lorenzo Caggiano is a member of the organising committee of Cancer Research at Bath (CR@B)
Efficient Synthesis of Biologically Active Molecules
We are currently investigating the efficient synthesis of simplified analogues of various biologically active compounds as potential therapeutics and have several projects at various stages. At present we have four novel classes of compounds under investigation by the National Cancer Institute (NCI). A flow chart showing the progress of our projects can be seen here.
Our work in the design and synthesis of novel analogues of natural products obtained from daffodils also features in the University of Bath Research Brochure.
Capture and Functionalisation of CO2
During the course of our investigations, we discovered a new transformation in which CO2 was sequestered from the atmosphere and functionalised. We are investigating the potential of using this transformation to industrial applications.
Novel Prenylation Reactions
We have discovered an efficient procedure for the prenylation of various substituted arenes.
Design and Synthesis of Fluorescent Sensors for Cd2+ and Zn2+
We are currently investigating the potential of some of our compounds as "turn on" fluorescent sensors for Cd2+ and Zn2+, which will find various applications.
Use of Metal Chelates as Molecular Scaffolds
Our interests also include the design and synthesis of metal chelators and their application as molecular scaffolds, generating 3D biological systems. We report the synthesis of a maltol-derived hydrazide and its potential to induce multicellular aggregation of modified cells selectively in the presence of Fe(III) ions within minutes.