Caggiano Group Webpages
Administrative DutiesDirector of Studues for Postgraduate Research Students; Departmental Higher Degrees Committee member; Member of the Department Learning, Teaching & Quality Committee (DLTQC); Deputy Work Load Model co-ordinator; member of the Research Staff Working Group; Departmental Research Staff Co-ordinator; Widening Participations departmental representative; Departmental Outreach Contact; Departmental Web Contact for News and Twitter.
- Nominated for the University John Willis Teaching Award 2014.
- Received a Faculty of Science "Recognising Excellence" Award 2014
- Nominated and awarded the University John Willis Teaching Award 2015.
- Received an Outstanding Contribution Award 2015, "in recognition for sustained exceptional performance over the past year".
Group InterestsCancer Research at Bath (CR@B)
Lorenzo Caggiano is a member of the organising committee of Cancer Research at Bath (CR@B). Gave an overview of cancer research activities in Medicinal Chemistry in Bath during a public lecture as part of the FutureLearn Massive Open Online Course (MOOC) on cancer.
Efficient Synthesis of Biologically Active Molecules
We are currently investigating the efficient synthesis of simplified analogues of various biologically active compounds as potential therapeutics and have several projects at various stages. At present we have four novel classes of compounds under investigation by the National Cancer Institute (NCI). A flow chart showing the progress of our projects can be seen here.
Our work in the design and synthesis of novel analogues of natural products obtained from daffodils for the treatment of cancer was the subject of an interview with Dr Phil Hammond for BBC Radio Bristol “Saturday Surgery” programme (listen here) and also features in the University of Bath Research Brochure. Our research was also the subject of a recent blog.
In collaboration with Dr Giordano Pula, we have been awarded £219,000 by the British Heart Foundation to explore novel prodrugs developed by our group for preventing strokes. News item.
Capture and Functionalisation of CO2
During the course of our investigations, we discovered a new transformation in which CO2 was sequestered from the atmosphere and functionalised. We are investigating the potential of using this transformation to industrial applications.
Novel Prenylation Reactions
We have discovered an efficient procedure for the prenylation of various substituted arenes.
Design and Synthesis of Fluorescent Sensors for Cd2+ and Zn2+
We are currently investigating the potential of some of our compounds as "turn on" fluorescent sensors for Cd2+ and Zn2+, which will find various applications.
Use of Metal Chelates as Molecular Scaffolds
Our interests also include the design and synthesis of metal chelators and their application as molecular scaffolds, generating 3D biological systems. We report the synthesis of a maltol-derived hydrazide and its potential to induce multicellular aggregation of modified cells selectively in the presence of Fe(III) ions within minutes.
Tweets by @LorenzoCaggiano