Welcome to the Mason Laboratory
Jody M. Mason
Professor of Biochemistry
University of Bath
Department of Biology & Biochemistry
Bath, BA2 7AY, United Kingdom
Our research interests centre on protein-protein interactions, particularly helical, coiled coil and amyloid-based proteins, and understanding how key interactions achieve stability and specificity. We use the Protein-fragment Complementation Assay (PCA) to screen libraries and select peptides or proteins with significant improvements in stability over wild-type interactions. Specificity of protein-protein interactions can be further improved by using a Competitive And Negative Design Initiative (CANDI) which I have developed to maximise the energy barrier between desired and non-desired protein pairs. Work currently being undertaken includes:
-Design and screening of coiled coil based libraries, particularly for oncogenic transcriptional regulator proteins, to investigate the role of key residues in stability and specificity.
-Monitoring the folding of natural and designed variants of protein-protein interactions to understand how stability and specificity is manifested at the kinetic level.
-Generating peptides to bind, reverse, and prevent amyloid fibril formation, particularly for beta-amyloid, the primary factor implicated in Alzheimers disease.
-Development of our Wellcome Trust funded game 'Cascade' - being designed in collaboration with Fayju. Cascade seeks to increase Alzheimer's disease awareness, understanding, empathy, and to highlight the desperate need for a cure.
Editorial Board Memberships:
-Future Medicinal Chemistry
-Alzheimers Research UK Grant Review Board (2017-21).
-BBSRC Core Member for Panel D (2019-2023).
-EPSRC Peer Review College (2016-21).
-Member of the Alzheimers Research UK Network
-Member of BRACE: The Bristol and Bath Alzheimers charity
-12/2018. CRUK Pioneer Award
-10/2018. BBSRC Project Grant
-10/2018. Alzheimers Research UK Major Project Grant
-10/2018. Alzheimers Society PhD Studentship
-01/2017. BRACE PhD Studentship
-01/2016. Biochemical Society Scientific Outreach Grant
-09/2014. EPSRC Overseas Travel Grant
-10/2012. BBSRC Industrial CASE Studentship (with Isogenica)
-06/2012. Wellcome Trust People Award (With Fayju)
-08/2011 Eppendorf Young Investigator Award (Runner up)
-06/2011. Royal Society Research Grant (with N Kad)
-10/2010. Parkinsons UK PhD Studentship (with N Kad)
-09/2010. Cancer Research UK Career Establishment Award
-05/2010. Wellcome Trust Project Grant
-01/2010. Research into Ageing New Investigator Award
-09/2008. Alzheimers Research Trust Pilot Project
-03/2008. Royal Society Research Grant
-11/2007. Royal Society Conference Grant
Information for Applicants:
We support applications for external or personal postdoctoral fellowships (e.g. EMBO, HFSP, Marie Curie or government funded) as well as applications from students intending to self-fund their PhD. Please contact Jody Mason for informal discussions.