Publications
2024
- Yu, M., Tang,
T.M.S., Ghamsari, L., Yuen G., Scuoppo C., Rotolo, J.A., Kappel, B.J, and Mason, J.M.
Exponential Combination of a and e/g Intracellular Peptide
Libraries Identifies a Selective ATF3 Inhibitor. ACS Chem Biol (In Press).
2023
- Tang, T.M.S., and
Mason, J.M. Intracellular application of an asparaginyl
endopeptidase for producing recombinant head-to-tail cyclic proteins. JACS
Au (In Press).
- Allen
S.G., Meade R.M., White Stenner L.L., Mason J.M. Peptide-based Approaches
to Directly Target Alpha-Synuclein in Parkinsons disease. Mol
Neurodegen 18:80 (2023).
- Meade,
R.M., Allen S.G., Williams, C., Tang, T.M.S., Crump, M.P., and Mason, J.M.
An N-terminal alpha-Synuclein fragment binds lipid vesicles to modulate
lipid induced aggregation. Cell. Rep. Phys. Sci. 4, 101563 (2023).
- Watt, K.J.C., Meade. R.M., James, T., Mason
J.M. Development of a hydroxyflavone-labelled
4554W peptide probe for monitoring alpha-Synuclein aggregation. Sci.
Rep. 13:10968 (2023).
2022
- Brennan
A., Leech J.T., Kad N.M., and Mason J.M. The Effect of Helix-Inducing
Constraints and Downsizing Upon a Transcription Block Survival Derived
Functional cJun Antagonist. Cell. Rep. Phys. Sci. 3, 101077 (2022).
- Nadal‑Bufi F., Chan L.Y., Mohammad H.H., Mason J.M., Salomon
C., Lai A., Thompson E.W., Craik D.J., Kaas Q., and Henriques S.T. Peptide‑based
LDH5 inhibitors enter cancer cells and impair proliferation Cell Mol
Life Sci 79:606 (2022)
- Watt K.J.C., Meade, R.M.,
Williams R.J., and Mason, J.M. Anionic lipid vesicles have differential
effects on the aggregation of early-onset associated alpha-synuclein
missense mutants. J. Biol. Chem.
298(12) 102565 (2022).
- Leech
J.T., Brennan A., Don N.A., Mason J.M., and Kad N.M. In vitro
Single molecule and bulk phase studies reveal the AP-1 transcription
factor cFos binds to DNA without cJun. J.
Biol. Chem 298(8) 10229 (2022).
- Darvishi
E., Ghamsari L., Leong S.F., Ramirez R., Koester
M., Gallagher E., Yu M., Mason J.M., Merutka G.,
Kappel B.J. Anti-cancer activity of ST101, a novel antagonist of
CCAAT/enhancer binding protein β. Mol Cancer Ther
21(11) 1632-44 (2022).
- Brennan A., Leech
J.T., Kad N.M., and Mason J.M. An Approach to Derive Functional
Antagonists of Transcription Factor Activity. JACS Au. 2, 4,
996-1006 (2022)
- Watt K.J.C.,
Meade R.M., Williams R.J., and Mason J.M. Library-derived peptide
aggregation modulators of Parkinson's disease early-onset alpha-synuclein
variants. ACS Chem. Neurosci. 13, 12, 1790-1804 (2022).
2021
- Meade,
R.M., Watt, K.J.C., Williams, R.J., and Mason. J.M. A Downsized and Optimised
Intracellular Library-derived Peptide Prevents α-Synuclein Primary
Nucleation and Toxicity Without Impacting Upon Lipid Binding. J. Mol. Biol. 433:167323
(2021).
- Nadal-Bufi, F., Mason,
J.M. Chan, L.Y., Craik, D.J., and Henriques, S.T. Designed beta-Hairpins Inhibit LDH5 Oligomerization and
Enzymatic Activity. J. Med. Chem 64(7) 3767-79 (2021).
- Hole K.L., Staniaszek
L.E., Balan G.M., Mason J.M., Brown J.T., Williams R.J. Oral (-)-Epicatechin
Inhibits Progressive Tau pathology in rTg4510 Mice Independent of Direct
Actions at GSK3β. Front Neurosci 15:697319 (2021).
- Yu,
M., Ghamsari, L., Rotolo, J.A., Kappel, B.J. and
Mason, J.M. Combined Computational and Intracellular Peptide Library
Screening: Towards a Potent and Selective Fra1 Inhibitor. RSC Chem Biol 2, 656-668 (2021).
- Madden S.K., Dantas de
Araujo A., Gerhardt M., Fairlie D.P., and Mason J.M.
Taking the Myc out of Cancer: Toward Therapeutic Strategies to Directly
Inhibit c-Myc. Molecular Cancer 20(3)
(2021).
- Kwok,
A., Camacho I., Winter S., Knight M., Meade R., van der Kamp M., Turner
A., O'Hara J., Mason J.M, Jones A, Arcus V., Pudney
C.R. A Thermodynamic
Model for Interpreting Tryptophan Excitation-energy-dependent Fluorescence
Spectra Provides Insight into Protein Conformational Sampling and
Stability. Front. Mol. Biosci. 8:778244
(2021).
2020
- Meade,
R.M., Williams, R.J. and Mason, J.M. A Series of Helical Alpha-synuclein
Fibril Polymorphs Are Populated in the Presence of Lipid Vesicles. Nature Partner Journal - Parkinsons
disease 6(20), (2020).
- Meade,
R.M., Morris, K.J., Watt, K.J.C., Williams, R.J., and Mason. J.M. The
Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein. J. Mol. Biol. 432, 166706 (2020).
- Torpey, J.H., Meade, R.M., Mistry, R., Mason, J.M., and Madine, J. Insights Into
Peptide Inhibition of Alpha-Synuclein Aggregation. Frontiers in Neuroscience 14, p1082 (2020)
- Brennan, A.,
Leech, J.T., Kad, N.M., and Mason J.M. Selective Antagonism of cJun as a
Cancer Therapy. J Exp Clin Cancer
Res 39(1) (2020).
- Leech J.T.,
Don N.A., Mason J.M*., and Kad N.M*. Single molecule imaging reveals cFos
is capable of binding to and diffusing on DNA tightropes independently of cJun submitted (biorxiv) *corresponding
authors.
- Lathbridge, A., Michalowska, A.,
Mason, J.M. Coupling Computational and Intracellular Screening and
Selection Towards Co-compatible cJun and cFos Antagonists. Biochemistry 59(4), 530-540
(2020).
2019
- Hoang, H.N,
Hill, T.A., Ruiz-Gomez, G., Diness, F., Mason,
J.M. Wu, C., Abbenante, G., Shephard, N.E., and Fairlie, D.P. Twists or Turns: Stabilising alpha vs.
beta-turns in tetrapeptides Chem.
Sci., 10, 10595-600 (2019).
- Meade, R., Fairlie, D.P., and Mason, J.M. Alpha-Synuclein
Structure and Parkinsons Disease: Lessons and Emerging Principles. Mol Neurodegener
14:29 (2019).
- Lathbridge, A and Mason, J.M. Combining Constrained
Heptapeptide Cassettes With Computational Design
to Create Coiled Coil Targeting Helical Peptides. ACS Chem. Biol 14,
1293-1304 (2019).
- Gulacsy C., Meade R., Catici
D., Soeller C., Pantos, G., Jones D., Alibhai
D., Jepson M., Valev V., Mason, J.M*. Williams
R.J*., Pudney C.R*. An
excitation-energy-dependent molecular beacon detects early-stage
neurotoxic Abeta aggregates in the presence of
cortical neurons. ACS Chem. Neurosci. 10, 1240-1250 (2019).
*corresponding authors.
2018
2017
- Baxter D.,
Ullman C.G., Frigotto L., and Mason J.M.
Exploiting Overlapping Advantages of in vitro and in cellulo
Selection Systems to Isolate a Novel High-affinity cJun
Antagonist. ACS Chem Biol 12,
2579-2588 (2017).
- Baxter D.,
Perry S., Hill T.A., Woan K., Zaccai N., Brady L., Fairlie
D.P., and Mason J.M. Helix-constrained Fos-based
peptides inhibit oncogenic Activator Protein-1 and cancer cell
proliferation. ACS Chem Biol 12,
2051-2061 (2017).
- McDowall,
J., Ntai, I., Hake, J., Whitley, O., Mason,
J.M., Pudney, C.R., and Brown, D.R. Steady-state
kinetics of alpha-synuclein ferrireductase activity identifies the
catalytically competent species. Biochemistry.
56, 2497-2505 (2017).
- Crooks,
R.O., Lathbridge A., Panek,
A., and Mason J.M. Computational Prediction
and Design to Create Iteratively Larger Heterospecific Coiled Coil Sets.
Biochemistry. 56, 1573-84 (2017).
2016
- Shepherd
N.E., Harrison R.S., Ruiz-Gomez G., Abbenante
G., Mason J.M., and Fairlie D.P. Downsizing the
BAD BH3 peptide to small constrained α-helices with improved ligand
efficiency. Org Biomol Chem 14,
10939-45 (2016).
- Crooks
R.O., Baxter, D., Panek, A.S., Lubben, A.T. and Mason J.M. Deriving Heterospecific
Self-assembling Protein-Protein Interactions Using
a Computational Interactome Screen. J.
Mol. Biol. 428, 385-398 (2016).
2015
2014
- Baxter D.,
Ullman, C.G., and Mason J.M. Library construction, selection and
modification strategies to generate therapeutic peptide-based modulators
of protein-protein interactions. Future Med. Chem. 6, 2073-2092
(2014).
- Acerra, N.,
Kad, N.M., Cheruvara, H., and Mason J.M.
Intracellular Selection of peptide Inhibitors that Target
Disulphide-Bridged Abeta42 Oligomers Protein Science 23, 1262-1274
(2014).
- Acerra, N.,
Kad, N.M., Griffith D.A., Ott, S., Crowther D.C., and Mason, J.M. Retro-inversal of Intracellular Selected Aβ Interacting
Peptides: Implications for a Novel Alzheimers
Disease Treatment. Biochemistry 53(13), 2101-2111 (2014).
2013
- Rao, T.,
Ruiz-Gomez G., Hill, T.A., Hoang H.N., Fairlie,
D.P., and Mason, J.M. Truncated and helix-constrained peptides with high
affinity and specificity for the cFos coiled-coil of AP-1. PLOS One.,
8(3), e59415 (2013).
2012
2011
- Crooks,
R.O., Rao, T., and Mason, J.M. Truncation, Randomisation and Selection:
Generation of a Reduced Length cJun Antagonist that Retains High
Interaction Stability. J. Biol. Chem., 286, 29470-9 (2011).
- Worrall,
J.A.R. and Mason, J.M. Thermodynamic Analysis of Jun-Fos
Coiled-coil Peptide Antagonists: Inferences for Optimisation of Enthalpic
Binding Forces. FEBS. J., 278(4) 663-672 (2011).
2010
2009
- Mason, J.M.
Electrostatic Contacts in the Activator Protein-1 Coiled Coil Enhance
Stability Predominantly by Decreasing the Unfolding Rate. FEBS. J.
276, 7305-7318 (2009).
- Mason, J.
M., Hagemann, U. B., and Arndt, K. M. Role of Hydrophobic and
Electrostatic Interactions in Coiled Coil Stability and Specificity. Biochemistry,
48, 10380-10388 (2009).
- Mason,
J.M., Muller, K.M. & Arndt, K.M., Peptides Tailored to Interfere with
Protein Interaction and Function. Chemistry Today. Vol 27(2),
47-50, (2009).
2008
- Mason,
J.M., Mueller, K.M., and Arndt, K.M., iPEP:
Peptides Designed and Selected for Interfering with Protein Interaction
and Function. Biochem. Soc. Trans., 36,
1442-1447 (2008).
- Hagemann,
U.B., Mason, J.M., Muller, K.M. and Arndt, K.M., Selectional
and mutational scope of peptides sequestering the Jun-Fos
coiled-coil domain, J. Mol. Biol. 381, 73-88 (2008).
- Willemsen
T, Hagemann U.B., Jouaux E.M., Stebel S.C., Mason J.M., Muller K.M., and Arndt K.M.,
Protein Engineering. Book Chapter in Molecular Biomethods
Handbook, 2nd Edition, Eds John M Walker and Ralph Rapley
(2008).
2007
- Mason,
J.M., Hagemann, U., Arndt, K.M., Improved stability of the Jun−Fos Activator Protein-1 coiled coil motif: A
stopped-flow circular dichroism kinetic analysis J. Biol. Chem.
282, 23015-23024 (2007).
- Mason,
J.M., Muller, K.M., and Arndt. K.M., Positive Aspects of Negative Protein
Design: Simultaneous Selection of Specificity and Stability. Biochemistry,
46, 4804-4814 (2007).
- Mason,
J.M., Muller, K.M., and Arndt K.M., Considerations in the Design and
Optimization of Coiled coil Structures. Methods. Mol. Biol., 352,
35-70 (2007).
- Hecky, J., Mason, J.M., Arndt, K.M., and Muller, K.M., A
General Method of Terminal Truncation, Evolution, and Re-Elongation to
Generate Enzymes of Enhanced Stability. Methods. Mol. Biol., 352,
275-304 (2007).
2006
- Mason,
J.M., Muller, K.M., Schmitz, M.A., and Arndt, K.M., Semirational
Design of Jun-Fos Coiled coils with Increased
Affinity: Universal Implications in Leucine zipper Prediction and Design. P.N.A.S.
103, 8989-8994, (2006). Supporting Information
- Kokkoni, N., Stott, K., Amijee,
H., Mason, J.M., and Doig, A.J., N-Methylated Peptide Inhibitors of
beta-Amyloid Aggregation and Toxicity. Optimisation of Inhibitor
Structure. Biochemistry, 45, 9906-9918, (2006).
- Compton,
E.L.R., Farmer, N.A., Lorch, M., Mason, J.M., Moreton, K.M., and Booth,
P.J., Kinetics of an Individual Transmembrane Helix during
Bacteriorhodopsin Folding, J. Mol. Biol. 357, 325-38, (2006).
- Doig, A.J.,
Kokkoni, N., Stott, K., Amijee,
N., Bottomley, J., Mason, J.M., Treherne, M.,
and Scope, D., N-methylated inhibitors of beta-smyloid
aggregation. Alzheimers and Dementia:
The Journal of the Alzheimer's Association, 2(3), Page S605 (2006).
2005
2004
- Mason,
J.M., and Arndt K.M., Coiled coils: stability, specificity, and biological
implications. Chembiochem., 5, 170-6,
(2004).
- Doig,
A.J., Kokkoni, N., Mason, J.M., Amijee, H., Stott, K., Treherne,
M., N-methylated Peptide Inhibitors of Abeta
Aggregation. Neurobiology of Aging., 25, S576, (2004).
2003
2002
- Mason,
J.M., Gibbs, N., Sessions, R.B., and Clarke A.R., The Influence of
Intramolecular Bridges on the Dynamics of a Protein Folding Reaction. Biochemistry,
40, 12093-12099, (2002).
2000
1999
- Lorch, M.,
Mason, J.M., Clarke, A.R., and Parker, M.J., Effects of Core Mutations on
the Folding of a β-sheet Protein: Implications for Backbone
Organisation in the I-state Biochemistry, 38, 1377-1385, (1999).
Patents: