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Chiral
veterinary medicines in the environment |
Funder: European
Commission, Marie Curie Actions, EIF Project No: 629015 |
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Dr María Dolores Camacho-Muñoz Marie
Curie Postdoctoral IEF Fellow Dr
Maria Dolores Camacho Muñoz is a Marie Curie Postdoctoral IEF Fellow at the
University of Bath since 2014. Originally from Spain she completed her PhD in
Chemistry at the University of Seville (Spain) in 2013. She also obtained a
Master of Science in Advanced studies in Chemistry (University of Seville)
and a Master in Quality Management Systems (IMF Business School, Spain). Dr.
Camacho Muñoz is a co-author of 16 papers in international journals. |
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Veterinary
pharmaceuticals are potent environmental contaminants. Research has been
undertaken to understand their environmental fate and toxicity. However, one
very important phenomenon has been overlooked and it is that more than half of
the drugs currently in use are chiral compounds. Chiral
compounds exist in the form of enantiomers, which have similar
physicochemical properties but they differ in their biological properties
and, therefore, in their potency, toxicity and environmental fate. Because
most studies on chiral pharmaceuticals do not explicitly account for
individual stereoisomers, they implicitly and incorrectly assume that
enantiomers have identical environmental behaviour. Furthermore, there is
also a lack of information concerning enantioselective toxicity of chiral
pharmaceuticals in the environment. This might lead to a significant under-
or overestimation of their toxicity, as well as, an incorrect environmental risk
assessment. Trace
analysis of pharmaceuticals in environmental samples is always challenging
due to the complexity and diversity of sample matrices, and until today, only
a few chiral analytical methods for environmental trace-level determinations
have been developed. Most of them focused on a few pharmaceuticals, and none
of them targeted veterinary pharmaceuticals of environmental relevance. This
proposal concerns: (i) the development and validation of methods for
enantiomeric analysis of a group of chiral veterinary medicines of
environmental relevance in environmental matrices using microextraction
techniques and liquid chromatography coupled with tandem mass spectrometry,
(ii) the study of their environmental fate and their toxicity effects towards
different organisms and (iii) the evaluation of the environmental risk posed
by these compounds. |
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Objective 1: To
develop and validate reliable multi-residue analytical methods for the
quantification of chiral veterinary medicines in environmental matrices using
microextraction techniques and determination by LC-MS/MS Objective 2: To
analyse enantiomers of chiral veterinary medicines and their metabolites in
the aqueous environment to study their environmental fate and their toxicity
effects towards different organisms from different trophic levels Objective 3: To
evaluate the environmental risk posed by these compounds |
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Publications: Camacho-Muñoz, D. and Kasprzyk-Hordern,
B., 2015. Multi-residue enantiomeric analysis of human and veterinary
pharmaceuticals and their metabolites in environmental samples by chiral
liquid chromatography coupled with tandem mass spectrometry detection.
Analytical and Bioanalytical Chemistry, 407 (30), pp. 9085-9104. Camacho-Muñoz, D., Petrie, B.,
Castrignano, E. and Kasprzyk-Hordern, B., 2015. Enantiomeric Profiling of
Chiral Pharmacologically Active Compounds in the Environment with the usage
of chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry.
Current Analytical Chemistry, 12. Petrie, B.,
Camacho-Munoz, M., Castrignano, E., Evans, S. and Kasprzyk-Hordern, B., 2015.
Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry for
Environmental Analysis of Pharmacologically Active Compounds. LCGC Europe, 2
(28), p. 151. Presentations: Camacho-Munoz, M.
and Kasprzyk-Hordern, B., 2015. Enantioselective determination of chiral pharmaceuticals
and veterinary medicines in environmental samples with an α1- acid
glycoprotein column and liquid chromatography-tandem mass spectrometry. In:
15th EuCheMS International Conference on Chemistry and the Environment,
2015-09-20 - 2015-09-25, Leipzig. Camacho-Muñoz,
M.D., Kasprzyk-Hordern, B., ‘Analysis of the chiral antineoplastic drug
ifosfamide in environmental samples by solid-phase extraction and liquid
chromatography-tandem mass spectrometry’ in ‘Emerging contaminants in waters and
soils, practical considerations: Sampling, analysis and consequences’, RSC
Water Science Forum, Sheffield, 4th of March 2015 |
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Dr Barbara Kasprzyk-Hordern, University
of Bath, Department of Chemistry, Bath BA2 &AY, UK, mailto:B.Kasprzyk-Hordern@bath.ac.uk