Lewis Research Group

Synthetic Methodology & Natural Product Synthesis


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42.) “Azulene–Thiophene–Cyanoacrylic acid dyes with donor-π-acceptor structures. Synthesis, characterisation and evaluation in dye-sensitized solar cells”, Cowper, P*; Pockett, A.; Kociok-Köhn, G.; Cameron, P. J.; Lewis, S. E*, Tetrahedron, 2018, 74, 2775–2786.   doi:10.1016/j.tet.2018.04.043     [Open-Access]



41.) “Self-assembly and surface behaviour of pure and mixed zwitterionic amphiphiles in a deep eutectic solvent”, Sanchez-Fernandez, A.; Moody, G. L.; Murfin, L. C.; Arnold,T.; Jackson, A. J.; King, S. M.; Lewis, S. E.; Edler, K. J., Soft Matter, 2018, 14, 5525-5536.   doi:10.1039/c8sm00755a     [Open-Access]



40.) “Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance”, Andrés-Costa, M. J.; Proctor, K.; Sabatini, M. T.; Gee, A. P.; Lewis, S. E.; Pico, Y.; Kasprzyk-Hordern, B., Sci. Rep., 2017, 7, 15777.   doi:10.1038/s41598-017-15585-1     [Open-Access]



39.) “Azetidinium lead iodide for perovskite solar cells”, Pering, S. R.; Deng, W.; Troughton, J. R.; Kubiak, P. S.; Ghosh, D.; Niemann, R. G.; Brivio, F.; Jeffrey, F. E.; Walker, A. B.; Islam, M. S.; Watson, T. M.; Raithby, P. R.; Johnson, A. L.; Lewis, S. E.; Cameron; P. J.*, J. Mater. Chem. A, 2017,5, 20658-20665.  doi:10.1039/C7TA07545F     [Open-Access]



38.) “Biocatalytic dearomatisation of para-fluorobenzoic acid – Access to versatile homochiral building blocks with quaternary centres”, Nash, T. J.; Wharry, S.; Moody, T. S.*; Lewis, S. E.*, Chimica Oggi, 2017, 35, 90–94. http://www.teknoscienze.com/tks_article/biocatalytic-dearomatisation-of-para-fluorobenzoic-acid-access-to-versatile-homochiral-building-blocks-with-quaternary-centres/     [Open-Access]



37.) “Azulene–boronate esters: colorimetric indicators for fluoride in drinking water”, López-Alled, C. M.; Sanchez-Fernandez, A.; Edler, K. J.; Sedgwick, A. C.; Bull, S. D.; McMullin, C. L.; Kociok-Köhn, G.; James, T. D.*; Wenk, J.*; Lewis, S. E.*, Chem. Commun., 2017, 53, 12580­–12583.   doi:10.1039/c7cc07416f   [Open-Access]



36.) “Phosphorus-substituted azulenes accessed via direct Hafner reaction of a phosphino cyclopentadienide”, Gee, A. P.; Cosham, S. D.; Johnson, A. L.; Lewis, S. E.* Synlett, 2017, ASAPdoi:10.1055/s-0036-1589936



35.) “What difference does a thiophene make? Evaluation of a 4,4’-bis(thiophene) functionalised 2,2’-bipyridyl copper(I) complex in a dye-sensitized solar cell”, Wills, K. A.; Mandujano-Ramírez, H. A.; Merino, G.; Oskam, G.; Cowper, P.; Jones, M. D.*; Cameron, P. J.*; Lewis, S. E.*  Dyes and Pigments, 2016, 134, 419-426.  doi:10.1016/j.dyepig.2016.07.023   [Open-Access]



34.) “Asymmetric Dearomatization Under Enzymatic Conditions”, Lewis, S. E. in Asymmetric Dearomatization Reactions (You, S.-L. ed.) Wiley-VCH, 2016, pp 279–346.  doi:10.1002/9783527698479.ch12



33.) “Langmuir monolayers composed of single and double tail sulfobetaine lipids”, Hazell, G.; Gee, A. P.; Arnold, T.; Edler, K.*; Lewis, S. E.  J. Colloid Interface Sci., 2016, 474, 190-198.  doi:10.1016/j.jcis.2016.04.020   [Open-Access]



32.) “Azulenesulfonium Salts: Accessible, Stable and Versatile Reagents for Cross-Coupling”, Cowper, P.*; Jin, Y.; Turton, M. D.; Kociok-Köhn, G.; Lewis, S. E.* Angew. Chem. Int. Edn., 2016, 55, 2564-2568.  doi:10.1002/anie.201510666   [Open-Access]



31.) “Biotransformations of Arenes: An Overview”, Lewis, S. E. in Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds (Mortier, J. ed.) Wiley-VCH, 2015, pp 915–937.  doi:10.1002/9781118754887.ch32



30.) “Tricarbonyliron(0) complexes of bio-derived η4 cyclohexadiene ligands: An approach to

analogues of oseltamivir”, ten Broeke, M.; Ali Khan, M.; Kociok-Köhn, G.; Kann, N.; Lewis, S. E.* J. Organomet. Chem., 2015, doi:10.1016/j.jorganchem.2015.09.005   [Open-Access]



29.) “Cycloparaphenylenes and related nanohoops”, Lewis, S. E.* Chem. Soc. Rev., 2015, 44, 2221-2304.  doi:10.1039/c4cs00366g   [Open-Access]



28.) “Direct core functionalisation of naphthalenediimides by iridium catalysed C-H borylation”, Lyall, C. L.; Shotton, C. C.; Pérez-Salvia, M.; Pantoş, G. D.*; Lewis, S. E.* Chem. Commun., 2014, 50, 13837-13840,  doi:10.1039/c4cc06522k   [Open-Access]



27.) “C-H functionalization of sp3 centers with aluminum: a computational and mechanistic study of the Baddeley reaction of decalin”, Lyall,C. L.; Sato, M.; Uosis-Martin, M.; Asghar, S. F.; Jones, M. D.; Williams, I. H.*; Lewis, S. E.* J. Am. Chem. Soc., 2014, 136, 13745-13753, doi:10.1021/ja5062246   [Open-Access]



26.) “A new assay for rhamnolipid detection—important virulence factors of Pseudomonas aeruginosa”, Laabei, M.; Jamieson, W. D.; Lewis, S. E.; Diggle, S. P.; Jenkins, A. T. A.*  Appl. Microbiol. Biotech., 2014, 98, 7199-7209,   doi:10.1007/s00253-014-5904-3  



25.) “The Enone Motif of (+)-Grandifloracin is Not Essential for “Anti-Austerity” Antiproliferative Activity”, Ali Khan, M.; Wood, Pauline J.; Lamb-Guhren, N. M.; Caggiano, L.; Kociok-Köhn, G.; Tosh, D.; Lewis, S. E.* Bioorg. Med. Chem. Lett., 2014, 24, 2815-2819.  doi:10.1016/j.bmcl.2014.04.111   [Open-Access]



24.) “Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis”,

Lewis, S. E.*  Chem. Commun., 2014, 50, 2821-2830.  doi:10.1039/c3cc49694e



23.) “Benzoate dioxygenase from Ralstonia eutropha B9 - unusual regiochemistry of dihydroxylation permits rapid access to novel chirons”, Griffen, J. A.; Kenwright, S. J.; Abou-Shehada, S.; Wharry, S.; Moody, T. S.*; Lewis, S. E.*  Org. Chem. Front., 2014, 1, 79-90.   doi:10.1039/c3qo00057e   [Open-Access]



22.) “Investigation of a copper(I) biquinoline complex for application in dye-sensitized

solar cells”, Wills, K. A.; Mandujano-Ramírez, H. J.; Merino, G.; Mattia, D.; Hewat, T.; Robertson, N.; Oskam, G.; Jones, M. D.; Lewis, S. E.; Cameron, P. J. RSC Advances, 20133, 23361-23369.  doi:10.1039/c3ra44936j



21.) “A Model System for the Synthesis of Complanadine Alkaloids by ‘Diverted Kondrat’eva’ Oxazole-Olefin Cycloaddition”, Uosis-Martin, M.; Pantoş, G. D.; Mahon, M. F.; Lewis, S. E.* J. Org. Chem., 2013, 78, 6253-6263.  doi:10.1021/jo401014n  



20.) “New Aminocyclitols with Quaternary Stereocentres via Acylnitroso Cycloaddition with an ipso,ortho-Arene Dihydrodiol”, Griffen, J. A.; White, J. C.; Kociok-Köhn, G.; Lloyd, M. D.; Wells, A.; Arnot, T. C.; Lewis, S. E.* Tetrahedron, 2013, 69, 5989-5997.  doi:10.1016/j.tet.2013.04.033   [Open-Access]



19.) “Aliphatic C-H Activation with Aluminium Trichloride-Acetyl Chloride: Expanding the Scope of the Baddeley Reaction for the Functionalisation of Saturated Hydrocarbons”, Lyall, C. L.; Uosis-Martin, M.; Lowe, J. P.; Mahon, M. F.; Pantoş, G. D.; Lewis, S. E.* Org. Biomol. Chem., 2013, 11, 1468-1475. doi:10.1039/c2ob26765a  **Front Cover Article**



18.) "Valuable New Cyclohexadiene Building Blocks via Cationic η5 Iron Carbonyl Complexes Derived from a Microbial Arene Oxidation Product”, Ali Khan, M.; Mahon, M. F.; Lowe, J. P.; Stewart, A. J. W.; Lewis, S. E.* Chem. Eur. J., 2012, 18, 13480-13493, doi:10.1002/chem.201202411



17.) "Photooxygenation of a Microbial Arene Oxidation Product and Regioselective Kornblum-DeLaMare Rearrangement. Total Synthesis of Zeylenols and Zeylenones”, Palframan, M. J.; Kociok-Köhn, G.; Lewis, S. E.* Chem. Eur. J., 2012, 18, 4766-4774,




16.) “TRPA1 Mediates Spinal Antinociception Induced by Acetaminophen and the Cannabinoid Δ9-Tetrahydrocannabiorcol”, Andersson, D. A.; Gentry, C.; Alenmyr, L.; Killander, D.; Lewis, S. E.; Andersson, A.; Bucher, B.; Galzi, J.-L.; Sterner, O.; Bevan, S.; Högestätt, E. D.; Zygmunt, P. M. Nature Commun., 2011, 2, 551, doi:10.1038/ncomms1559



15.) “A Cobalt Complex of a Microbial Arene Oxidation Product”, van der Waals, D.; Pugh, T.; Ali Khan, M.; Stewart, A. J. W.; Johnson, A. L.; Lewis, S. E.*  Chem. Central J., 2011, 5, 80, doi:10.1186/1752-153X-5-80   [Open-Access]



14.) “Concise Synthesis of 1,4a-Bifunctionalised Decalin Building Blocks by C-H Activation of Decalin”, Uosis-Martin, M.; Mahon, M. F.; Yevglevskis, M.; Lewis, S. E.* Synlett, 2011, 2211-2213, doi: 10.1055/s-0030-1261184



13.) “Synthetic methods Part (II): oxidation and reduction methods”, Asghar, S. F.; Lewis, S. E.* Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2011, 107, 34-67, doi:10.1039/c1oc90012a



12.) “Total Synthesis of (+)-Grandifloracin by Iron Complexation of a Microbial Arene Oxidation Product”, Palframan, M. J.; Kociok-Köhn, G.; Lewis, S. E.* Org. Lett., 2011, 13, 3150-3153, doi:10.1021/ol201057r   [Open-Access]



11.) “Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds”, Griffen, J. A.; Le Coz, A. M.; Kociok-Köhn, G.; Ali Khan, M.; Stewart, A. J. W; Lewis, S. E.* Org. Biomol. Chem., 2011, 9, 3920-3928, doi:10.1039/c1ob05131h



10.) “Inosaminoacids: novel inositol-amino acid hybrid structures accessed by microbial arene oxidation”, Pilgrim, S.; Kociok-Köhn, G.; Lloyd, M. D.; Lewis, S. E.* Chem. Commun., 2011, 47 4799-4801  doi:10/1039/c1cc10643k



9.) “Accessing the antipodal series in microbial arene oxidation: a novel diene rearrangement induced by tricarbonyliron(0) complexation”, Ali Khan, M.; Lowe, J. P.; Johnson, A. L.; Stewart, A. J. W.; Lewis, S. E.* Chem. Commun., 2011, 47, 215-217 doi:10.1039/c0cc01169j



8.) “Iron(0)tricarbonyl Complexes of Microbially-Derived Cyclohexadiene Ligands Containing Quaternary Stereocenters”, Ali Khan, M.; Mahon, M. F.; Stewart, A. J. W.; Lewis, S. E.* Organometallics, 2010, 29, 199-204.   doi:10.1021/om9009069



7.) “Transannular decarboxylative Claisen rearrangement reactions for the synthesis of sulfur-substituted vinylcyclopropanes”, Craig, D.*; Gore, S. J.; Lansdell, M. I.; Lewis, S. E.; Mayweg, A. V. M.; White, A. J. P. Chem. Commun., 2010, 46, 4991-4993.  




6.) “Synthesis and Characterisation of Novel Alkane-α,ω-diyl bis(silyl triflates)”, Baker, T.; Lewis, S. E.* Synth. Commun., 2010, 40, 2747-2752.    doi:10.1080/00397910903318724



5.) “Crystallographic rationalization of the reactivity and spectroscopic properties of (2R)-S-(2,5-dihydroxyphenyl)cysteine”, Kociok-Köhn, G.; Lewis, S. E.* Acta Cryst., 2010, C66, o187-o189.   doi:10.1107/S0108270110005780



4.) “Synthetic methods: Part (ii) Oxidation and reduction methods”, Lewis, S. E.* Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2010, 106, 34-75.   doi:10.1039/b927087f



3.) “Synthetic methods: Part (ii) Oxidation and reduction methods”, Lewis, S. E.* Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2009, 105, 35-74.   doi:10.1039/b822050f



2.) “Decarboxylative Claisen rearrangements of diallyl 2-sulfonylmalonates: remarkable regioselectivity in the reaction of bifunctional substrates”, Craig, D.*; Lansdell, M.; Lewis, S. E. Tetrahedron Lett., 2007, 48, 7861-7864.  doi:10.1016/j.tetlet.2007.08.130