Recent refereed publications from ISB and colleagues
1994:
19. I S Blagbrough and E Moya, Practical synthesis of the putative polyamine spider toxin FTX: a proposed blocker of voltage-sensitive calcium channels, Tetrahedron Letters, 1994, 35, 2057-2060.
20. E Moya and I S Blagbrough, Rapid practical syntheses of the arginyl polyamine sFTX-3.3: a blocker of voltage-sensitive calcium channels, Tetrahedron Letters, 1994, 35, 2061-2062.
21. L D Buckberry, H J Adcock, J Adler, I S Blagbrough, P J Gaskin, and P N Shaw, In vitro methods for the assessment of L-cysteine conjugate toxicity, Alternatives to Lab Animals, 1994, 22, 72-80.
22. I S Blagbrough, D J Hardick, S Wonnacott, and B V L Potter, Regioselective demethylation of aconitine, Tetrahedron Letters, 1994, 35, 3367-3370.
23. D J Hardick, I S Blagbrough, S Wonnacott, and B V L Potter, Regioselective anthranoylation of demethylated aconitine: novel analogues of aconitine, inuline, and methyllycaconitine, Tetrahedron Letters, 1994, 35, 3371-3374.
24. L D Buckberry, I S Blagbrough, B W Bycroft, and P N Shaw, Human renal, hepatic and pulmonary C-S lyases: possible catalysts for the biosynthesis of toxic thiols in phase 3 metabolism, Pharmaceutical Science Communications, 1994, 4, 107-116.
25. G Adlam, I S Blagbrough, S Taylor, H C Latham, I S Haworth, and A Rodger, Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine, Bioorganic Medicinal Chemistry Letters, 1994, 4, 2435-2440.
26. P A Coates, I S Blagbrough, D J Hardick, M G Rowan, S Wonnacott, and B V L Potter, Rapid and efficient isolation of the nicotinic receptor antagonist methyllycaconitine from Delphinium: assignment of the methylsuccinimide absolute stereochemistry as S, Tetrahedron Letters, 1994, 35, 8701-8704.
27. I S Blagbrough, P A Coates, D J Hardick, T Lewis, M G Rowan, S Wonnacott, and B V L Potter, Acylation of lycoctonine: semi-synthesis of inuline, delsemine analogues and methyllycaconitine, Tetrahedron Letters, 1994, 35, 8705-8708.
28. P A Coates, I S Blagbrough, M G Rowan, B V L Potter, D P J Pearson, and T Lewis, Rapid and efficient entry to substituted 2-succinimidobenzoate-3-azabicyclo[3.3.1]nonanes: AE-bicyclic analogues of methyllycaconitine, Tetrahedron Letters, 1994, 35, 8709-8712.
29. I S Blagbrough, E Moya, and S Taylor, Polyamines and polyamine amides from wasps and spiders, Biochemical Society Transactions, 1994, 22, 888-893.
30. A Rodger, I S Blagbrough, G Adlam, and M L Carpenter, DNA binding of a spermine derivative: spectroscopic study of anthracene-9-carbonyl-N1-spermine with poly[d(G-C).d(G-C)] and poly[d(A-T).d(A-T)], Biopolymers, 1994, 34, 1583-1593.
1995:
31. J Screen, E Moya, I S Blagbrough, and A W Smith, Iron uptake in Pseudomonas aeruginosa mediated by N-(2,3-dihydroxybenzoyl)-L-serine and 2,3-dihydroxybenzoic acid, FEMS Microbiology Letters, 1995, 127, 145-149.
32. D J Hardick, G Cooper, T Scott-Ward, I S Blagbrough, B V L Potter, and S Wonnacott, Conversion of the sodium channel activator aconitine into a potent a 7-selective nicotinic ligand, FEBS Letters, 1995, 365, 79-82.
33. A Rodger, S Taylor, G Adlam, I S Blagbrough, and I S Haworth, Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermine, Bioorganic Medicinal Chemistry, 1995, 3, 861-872.
34. R H Osborne, B Odell, and I S Blagbrough, Proctolin and related N-methylated pentapeptides selectively contract locust foregut but not rat ileum, Bioorganic Medicinal Chemistry Letters, 1995, 5, 2085-2088.
35. P A Coates, I S Blagbrough, T Lewis, B V L Potter, and M G Rowan, An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist, J Pharmaceutical Biomedical Analysis, 1995, 13, 1541-1544.
36. I S Blagbrough and E Moya, Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical reductive alkylation strategy, Tetrahedron Letters, 1995, 36, 9393-9396.
37. M R Ashton, E Moya, and I S Blagbrough, Total synthesis of modified JSTX toxins: reductive alkylation is a practical route to hexahydropyrimidine polyamine amides, Tetrahedron Letters, 1995, 36, 9397-9400.
38. E Moya and I S Blagbrough, Total syntheses of polyamine amides PhTX-4.3.3 and PhTX-3.4.3: reductive alkylation is a rapid, practical route to philanthotoxins, Tetrahedron Letters, 1995, 36, 9401-9404.
39. J M Hinton, R H Osborne, B Odell, S J Hammond, and I S Blagbrough, Cycloproctolin and [a -methyl-L-Tyr]-proctolin are potent antagonists of proctolin-induced inositol phosphate production in locust foregut homogenates, Bioorganic Medicinal Chemistry Letters, 1995, 5, 3007-3010.
1996:
40. J R B Dupere, E Moya, I S Blagbrough, and M M Usowicz, Differential inhibition of Ca2+ channels in mature rat cerebellar Purkinje cells by sFTX-3.3 and FTX-3.3, Neuropharmacology, 1996, 35, 1-11
41. S Carrington, M A Qarawi, I S Blagbrough, S H Moss, and C W Pouton, Inhibition of growth of B16 murine melanoma cells by novel spermine analogues, Pharmaceutical Sciences, 1996, 2, 25-27.
42. I S Blagbrough, E Moya, and S P Walford, Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3, Tetrahedron Letters, 1996, 37, 551-554.
43. E Moya and I S Blagbrough, Efficient syntheses of polyamine and polyamine amide voltage-sensitive calcium channel blockers: FTX-3.3 and sFTX-3.3, J Pharmacy Pharmacology, 1996, 48, 179-182.
44. P A Coates, I S Blagbrough, M G Rowan, D P J Pearson, T Lewis, and B V L Potter, Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist: rapid syntheses of AE-bicyclic analogues, J Pharmacy Pharmacology, 1996, 48, 210-213.
45. D J Hardick, I S Blagbrough, and B V L Potter, Isotopic enrichment by asymmetric deuteriation. An investigation of the synthesis of deuteriated (S)-(-)-methylsuccinic acids from itaconic acid, J American Chemical Society, 1996, 118, 5897-5903.
46. T M Norris, E Moya, I S Blagbrough, and M E Adams, Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3, Molecular Pharmacology, 1996, 50, 939-946.
47. D J Hardick, I S Blagbrough, G Cooper, B V L Potter, T Critchley, and S Wonnacott, Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal a-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding, J Medicinal Chemistry, 1996, 39, 4860-4866.
1997:
48. M Fatehi, E G Rowan, A L Harvey, E Moya, and I S Blagbrough, Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals, Neuropharmacology, 1997, 36, 185-194.
49. I S Blagbrough, S Carrington, and A J Geall, Polyamines and polyamine amides as potent selective receptor probes, novel therapeutic lead compounds and synthetic vectors in gene therapy, Pharmaceutical Sciences, 1997, 3, 223-233.
50. M A Qarawi, S Carrington, I S Blagbrough, S H Moss, and C W Pouton, Optimization of the MTT assay for B16 murine melanoma cells and its application in assessing the growth inhibition by polyamines and novel polyamine conjugates, Pharmaceutical Sciences, 1997, 3, 235-239.
1998:
51. I S Blagbrough and A J Geall, Practical synthesis of unsymmetrical polyamine amides, Tetrahedron Letters, 1998, 39, 439-442.
52. A J Geall and I S Blagbrough, Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes, Tetrahedron Letters, 1998, 39, 443-446.
53. G Grangier, W J Trigg, T Lewis, M G Rowan, B V L Potter, and I S Blagbrough, Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine, Tetrahedron Letters, 1998, 39, 889-892.
54. W J Trigg, G Grangier, T Lewis, M G Rowan, B V L Potter, and I S Blagbrough, Synthesis of novel unsaturated AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine: with olefinic J = 13.5 Hz, but still cis, Tetrahedron Letters, 1998, 39, 893-896.
55. W J Trigg, D J Hardick, G Grangier, S Wonnacott, T Lewis, M G Rowan, B V L Potter, and I S Blagbrough, Selective probes for nicotinic acetylcholine receptors from substituted AE-bicyclic analogs of methyllycaconitine, ACS Symposium Series, (Eds D R Baker, J G Fenyes, G S Basarab, and D A Hunt), 1998, 686, 194-205.
56. I S Blagbrough, S Taylor, M L Carpenter, V Novoselskiy, T Shamma, and I S Haworth, Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA, Chemical Communications, 1998, 929-930.
57. A J Geall, R J Taylor, M E Earll, M A W Eaton, and I S Blagbrough, Synthesis of cholesterol-polyamine carbamates: pKa studies and condensation of calf thymus DNA, Chemical Communications, 1998, 1403-1404.
58. X Doisy, I S Blagbrough, S Wonnacott, and B V L Potter, Design, synthesis, and biological evaluation of substituted benzoate analogues of the selective nicotinic acetylcholine receptor antagonist, methyllycaconitine, Pharmacy and Pharmacology Communications, 1998, 4, 313-317.
59. A J Geall, D Al-Hadithi, and I S Blagbrough, Spermine and thermine conjugates of cholic acid condense DNA, but lithocholic acid polyamine conjugates do so more efficiently, Chemical Communications, 1998, 2035-2036.
60. J L Davies, J N Staniforth, and I S Blagbrough, Electrorheological behaviour at low applied electric fields of microcrystalline cellulose in BP oils, Chemical Communications, 1998, 2157-2158.
61. S Carrington, A H Fairlamb, and I S Blagbrough, Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- and 28-membred rings, Chemical Communications, 1998, 2335-2336.
62. X Doisy, I S Blagbrough, N F Thomas, and B V L Potter, Studies on the substituted 3-aminopropan-1-ol motif of lycoctonine class norditerpenoid alkaloids: a novel route to 3-hydroxymethylcyclohex-2-enone, Tetrahedron Letters, 1998, 39, 8525-8528.
63. R H Scott, N M Thatcher, A Ayar, S J Mitchell, J Pollock, M T Gibson, I R Duce, E Moya, and I S Blagbrough, Extracellular or intracellular application of argiotoxin-636 has inhibitory actions on membrane excitability and voltage-activated currents in cultured rat sensory neurones, Neuropharmacology, 1998, 37, 1563-1578.
1999:
64. I S Blagbrough, D Al-Hadithi, and A J Geall, DNA condensation by bile acid conjugates of thermine and spermine, Pharmacy and Pharmacology Communications, 1999, 5, 139-144.
65. A J Geall and I S Blagbrough, DNA condensation by cholesterol polyamine carbamates: a first step in gene therapy, Pharmacy and Pharmacology Communications, 1999, 5, 145-150.
66. S Carrington, J Renault, S Tomasi, S Sinbandhit, I S Blagbrough, and P Uriac, Solid-phase organic synthesis of unnatural polyamine analogues bearing a dansyl or acridine moiety, Pharmacy and Pharmacology Communications, 1999, 5, 151-157.
67. A R L Davies, D J Hardick, I S Blagbrough, B V L Potter, A J Wolstenholme, and S Wonnacott, Characterisation of the binding of [3H]-methyllycaconitine: a new radioligand for labelling a7-type neuronal nicotinic acetylcholine receptors, Neuropharmacology, 1999, 38, 679-690.
68. S Carrington, J Renault, S Tomasi, J-C Corbel, P Uriac, and I S Blagbrough, A novel solid-phase reductive alkylation route to acridine and dansyl polyamine conjugates, Chemical Communications, 1999, 1341-1342.
69. P Whiteaker, A R L Davies, M J Marks, I S Blagbrough, B V L Potter, A J Wolstenholme, A C Collins, and S Wonnacott, An autoradiographic study of the distribution of binding sites for the novel a7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain, European J. Neuroscience, 1999, 11, 2689-2696.
70. A J Geall, M A W Eaton, T Baker, C Catterall, and I S Blagbrough, The regiochemical distribution of positive charges along cholesterol polyamine carbamates plays significant roles in modulating DNA binding affinity and lipofection, FEBS Letters, 1999, 459, 337-342.
2000:
71. A J Geall and I S Blagbrough, Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes, Tetrahedron, 2000, 56, 2449-2460.
72. A J Geall, R J Taylor, M E Earll, M A W Eaton, and I S Blagbrough, Synthesis of cholesteryl polyamine carbamates: pKa studies and condensation of calf thymus DNA, Bioconjugate Chemistry, 2000, 11, 13 pp in press May.
73. A J Geall and I S Blagbrough, Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate-DNA interactions for the analysis of lipoplex formation in gene therapy, J Pharmaceutical Biomedical Analysis, 2000, 22, 849-859 pp in press May.
74. I S Blagbrough, D Al-Hadithi, and A J Geall, Cheno-, urso-, and deoxycholic acid spermine conjugates: relative binding affinities for calf thymus DNA, Tetrahedron, 2000, 56, 8 pp in press June.
75. A J Geall, D Al-Hadithi, and I S Blagbrough, Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides, Bioconjugate Chemistry, 2000, 11, 12 pp submitted.