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Department of Chemistry


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Dr Stephen FlowerDr Stephen Flower

Director of Studies (MRes Chemistry and MSc Chemistry for Drug Discovery)

Teaching Fellow - Organic Chemistry and Drug Discovery

Tel: 01225 385508 (internal x5508)

Fax: 01225 386231

E-mail: S.E.Flower@bath.ac.uk

Address: Department of Chemistry, University of Bath, Bath BA2 7AY

Office: 1 South 1.25a

Lab: 1 South 0.27


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My Publications




"Not Chemistry"



Old Links:

Using the Plasma Reactor

Quick Guide to the Metal Evaporator

Current Position:

2013 - present: Teaching Fellow in Drug Discovery and Organic Chemistry

Currently teach in these modules:

First Year

Foundation Organic Laboratory (CH10009)
Chemistry of the Cell (CH10191)
Drug Properties and Physiology (CH10192)

Second Year

Organic Synthesis, reaction mechanisms and spectroscopy (CH20149-50)
Organic Chemistry Laboratory 2 (CH20021)
Organic Synthesis, reaction mechanisms and spectroscopy for Natural Science and Chemistry with Management Students - Laboratory (CH20150A)

Third/Fourth Year

Future of Drug Discovery (CH30120 / CH40120)
Topics in Organic Chemistry (CH30128)
Chemistry Research (CH30063)

Research Interests

In addition to teaching I have a number of research interests that cover continuation of my previous research: novel fluorescent sensors for biological and medical applications; and new areas that also tie in with my current teaching: Synthesis of novel benzothiophene antibiotics (part of the CH30063 module) and New reversibly cyclic peptides for anti-cancer therapies.

Publications: link

Previous Work:

2012-2013 Research Fellow - Novel Inorganic Fluorophores for Biolabelling

Continuation of work in 2009, in addition collaborating with AbCam Ltd.

2011-2012 Teaching Fellow - Drug Discovery and Organic Chemistry

2010-2011 Research Officer - Novel pH sensitive fluorophores for cell culture monitoring

Investigation of tethered pH responsive fluorophore for use in cell culture vessels to help monitor cell cultures being grown in vessels controlled by automation.

2009-2010 Teaching Fellow - Drug Discovery and Organic Chemistry

2008-2009 Research Officer - Novel Inorganic Fluorophores for Biolabelling

With Intrinsiq Materials Ltd, this project investigated new inorganic fluorophores as stable, inert alternatives to Quantum Dots, for use in labelling antibodies and other biological targets.

2007-2008 Teaching Fellow - Drug Discovery: Anticancer Drugs

Developed a new seven-lecture module on anti-cancer drugs, covering the aetiology of cancer and from that the different strategies used to develop anti-cancer drugs.

2006-2007 Fluorescent sensors for real-time blood glucose monitoring

Working for Dr Tony James in the Chemosensors group in the Department of Chemistry at the University of Bath in collaboration with Glysure Ltd.


One of our sensors after filtration, the boronic acid-containing sensor is non-fluorescent in the centre. Residual fluorophore without boronic acid glows at the filter paper edge.

Image taken by Bradley Vice

2004-2006 DNA diagnostics for clinical microbiology

This was a LINK Applied Genomics funded project between the University of Bath, University of Glasgow, Atlas Genetics Ltd and Stobhill Hospital, Glasgow.

This project aims to develop a novel platform technology for use in exploitation of genomic data from clinically important bacterial pathogens. The principal objectives were:

Optimisation of electrochemical DNA assays for selected bacteria.

Characterisation of appropriate electrode materials, sensor geometries and surface functionalisations to enhance detection sensitivity and specificity.

Incorporation of microsystems technology with DNA amplification and detection protocols.

The outcome of the project was an initial prototype microsystem.

We have developed a sensing system using an electroactive-labelled DNA probe; the label is detected upon release by digestion of probe-target hybridised DNA complex by a T7 exonuclease.

Assay Overview:

Images courtesy Dr Russell Keay

2002-2004 Synthesis of Novel Redox Probes for DNA detection

This was a TCS (now KTP) project (#3803) involving Drs Chris Frost and Toby Jenkins at the University of Bath and Molecular Sensing plc (now Atlas Genetics Ltd) developing redox probes for detection of DNA. During the tenure a large number of ferrocene-based redox probes were produced.

1998-2002 Lewis Acid Mediated Reactions of Olefins with Carbonyls

PhD under the supervision of Dr Michael Willis. Initial work involved an examination of the Desymmetrising Ene Cyclisation. This developed into natural product synthesis of bicyclic heterocycles using novel leaving-group chemistry.







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