Dr Stephen Flower
Director of Studies (MRes Chemistry and MSc Chemistry for Drug Discovery)
Teaching Fellow - Organic Chemistry and Drug Discovery
Tel: 01225 385508 (internal x5508)
Fax: 01225 386231
Department of Chemistry, University of Bath,
Office: 1 South 1.25a
Lab: 1 South 0.27
2013 - present: Teaching Fellow in Drug Discovery and Organic Chemistry
Currently teach in these modules:
Organic Synthesis, reaction mechanisms and spectroscopy (CH20149-50)
In addition to teaching I have a number of research interests that cover continuation of my previous research: novel fluorescent sensors for biological and medical applications; and new areas that also tie in with my current teaching: Synthesis of novel benzothiophene antibiotics (part of the CH30063 module) and New reversibly cyclic peptides for anti-cancer therapies.
2012-2013 Research Fellow - Novel Inorganic Fluorophores for Biolabelling
Continuation of work in 2009, in addition collaborating with AbCam Ltd.
2011-2012 Teaching Fellow - Drug Discovery and Organic Chemistry
2010-2011 Research Officer - Novel pH sensitive fluorophores for cell culture monitoring
Investigation of tethered pH responsive fluorophore for use in cell culture vessels to help monitor cell cultures being grown in vessels controlled by automation.
2009-2010 Teaching Fellow - Drug Discovery and Organic Chemistry
2008-2009 Research Officer - Novel Inorganic Fluorophores for Biolabelling
With Intrinsiq Materials Ltd, this project investigated new inorganic fluorophores as stable, inert alternatives to Quantum Dots, for use in labelling antibodies and other biological targets.
2007-2008 Teaching Fellow - Drug Discovery: Anticancer Drugs
Developed a new seven-lecture module on anti-cancer drugs, covering the aetiology of cancer and from that the different strategies used to develop anti-cancer drugs.
2006-2007 Fluorescent sensors for real-time blood glucose monitoring
Image taken by Bradley Vice
2004-2006 DNA diagnostics for clinical microbiology
This project aims to develop a novel platform technology for use in exploitation of genomic data from clinically important bacterial pathogens. The principal objectives were:
Optimisation of electrochemical DNA assays for selected bacteria.
Characterisation of appropriate electrode materials, sensor geometries and surface functionalisations to enhance detection sensitivity and specificity.
Incorporation of microsystems technology with DNA amplification and detection protocols.
The outcome of the project was an initial prototype microsystem.
We have developed a sensing system using an electroactive-labelled DNA probe; the label is detected upon release by digestion of probe-target hybridised DNA complex by a T7 exonuclease.
Images courtesy Dr Russell Keay
2002-2004 Synthesis of Novel Redox Probes for DNA detection
This was a TCS (now KTP) project (#3803)
involving Drs Chris
Frost and Toby
Jenkins at the
1998-2002 Lewis Acid Mediated Reactions of Olefins with Carbonyls
PhD under the supervision of Dr Michael Willis. Initial work involved an examination of the Desymmetrising Ene Cyclisation. This developed into natural product synthesis of bicyclic heterocycles using novel leaving-group chemistry.