Holman Group Publications (2000-2009)

Gillingham A.K., Koumanov F., Hashimoto M. and Holman G. D. (2000) Detection and analysis of glucose transporters using photolabelling techniques. pp 193-207. In "Membrane Transport: A Practical Approach" (Baldwin S A (ed ) Oxford Univerity Press)

Pryor P.R., Liu S.C., Clark A.E., Yang J., Holman G.D. and Tosh D. (2000) Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin. Biochem. J. 348, 83-91

Ryder J.W., Yang J., Galuska D., Rincón J., Björnholm M., Krook A., Lund S., Pedersen O., Wallberg-Henriksson H., Zierath J. R. and Holman G.D. (2000) Use of a Novel Impermeable Biotinylated Photolabeling Reagent to Assess Insulin and Hypoxia-Stimulated Cell Surface GLUT4 Content in Skeletal Muscle from Type II Diabetic Patients. Diabetes 49, 647-654

Sandoval I.V., Martinez-Arca S., Valdueza J., Palacios S. and Holman G.D. (2000) Distinct Reading of Different Structural Determinants Modulates the Dileucine-mediated Transport Steps of the Lysosomal Membrane Protein LIMPII and the Insulin-sensitive Glucose Transporter GLUT4. J. Biol. Chem. 275, 39874-39885

Tatibouët A., Yang J., Morin C. and Holman G.D. (2000) Synthesis and Evaluation of Fructose Analogues as Inhibitors of the D-Fructose Transporter GLUT 5. Bioorganic & Med. Chem. 8, 1825-1833

Hashimoto M., Yang J. and Holman G.D. (2001) Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: An example from glucose transporter probes. ChemBioChem 2, 52-59

Buhl E.S., Jessen N., Schmitz O., Pedersen S.B., Pedersen O., Holman G.D. and Lund S. (2001) Chronic treatment with 5-aminoimidazole-4-carboxamide-1-b-D- ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes 50, 12-17

Holman G.D. and Sandoval I. V. (2001) Moving the insulin-regulated glucose transporter GLUT4 into and out of storage. Trends Cell Biol. 11, 173-179

Hashimoto M., Hatanaka Y., Yang J., Dhesi J. and Holman G.D. (2001) Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling. Carbohydr. Res. 331, 119-127

Tatibouët A., Lefoix M., Nadolny J., Martin O.R., Rollin P., Yang J. and Holman G.D. (2001) D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5 Carbohydr. Res. 333, 327-334

Yang J., Hodel, A., and Holman, G.D. (2002) Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane. J. Biol. Chem. 277, 6559-6566

Whitley P., Gibbard A.M., Koumanov F., Oldfield S., Kilgour E.E., Prestwich G.D. and Holman G.D. (2002) Identification of centaurin-a2: a phosphatidylinositide-binding protein present in fat,heart and skeletal muscle. Eur. J. Cell Biol. 81, 222-230

Hashimoto M., Yang J., Hatanaka Y., Sadakane Y., Nakagomi K. and Holman G.D. (2002) Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring. Chem. Pharm. Bull. 50, 1004-1006

Yang J., Dowden J., Tatibouët A., Hatanaka Y. and Holman G.D. (2002) Development of high affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5. Biochem J. 367, 533-539


Yang J., Gillingham A.K., Hodel A., Koumanov F., Woodward B. and Holman G.D. (2002) Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes. Am. J. Physiol. Endrocrinol. Metab. 283, E1299-E1307


Girniene J., Tatibouët A., Sackus A., Yang J., Holman G.D. and Rollin P. (2003) Inhibition of the D-fructose transporter GLUT5 by fused-ring glyco-1,3-oxazolidine-2-thiones and oxazolidine-2-ones. Carbohydr. Res. 338, 711-719

Koistinen H.A., Galuska D., Chibalin A.V., Yang J., Zierath J.R., Holman G.D. and Wallberg-Henriksson H. (2003) 5-Amino-Imidazole Carboxamide Riboside Increases Glucose Transport and Cell-Surface GLUT4 Content in Skeletal Muscle From Subjects With Type 2 Diabetes. Diabetes 52, 1066-1072


Al Khalili L., Chibalin A.V., Kannisto K., Zhang B.B., Permert J., Holman G.D., Ehrenborg E., Ding V.D.,Zierath J.R. and Krook A. (2003) Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content. Cell Mol. Life Sci. 60, 991-998


Bentley J., Itchayanan D., Barnes K., McIntosh E., Tang X., Downes C.P., Holman G.D., Whetton A.D., Owen-Lynch P.J. and Baldwin S.A. (2003) Interleukin 3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J. Biol. Chem. 278, 39337-39348


Whitley P., Reaves B.J., Hashimoto M., Riley A.M., Potter B.V.L. and Holman G.D. (2003) Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5 bisphosphate dependent endosome compartmentalization. J. Biol. Chem. 278, 38786-38795

Tatibouet, A., Lawrence, S., Rollin, P. and Holman, G.D. (2004) Selective formation of 1,3-oxazolidine-2-thiones on ketohexose templates. Synlett 11, 1945-1948

Li J., Hu X., Selvakumar P., Russell R.R., III, Cushman S.W., Holman G.D. and Young L.H. (2004) Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol Endocrinol Metab 287, E834-E841

Yang J. and Holman G.D. (2005) Insulin and contraction stimulate exocytosis but increased AMPK activity resulting from oxidative-metabolism stress slows endocytosis of GLUT4 in cardiomyocytes. J Biol Chem 280, 4070-4078


Ribe, D., Yang, J., Patel S.,  Koumanov, F., Cushman, S.W. and Holman, G.D. (2005) Endofacial competitive inhibition of GLUT4 intrinsic activity by the MAP kinase inhibitor SB203580. Endocrinology, 146, 1713-1717


Collison, M., James, D. J., Graham, D., Holman, G. D., Connell, J. M., Dominiczak, A. F., Gould, G. W., and Salt, I. P. (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia 48, 539-546


Koumanov, F., Jin, B., Yang, J. and Holman, G. D.(2005) Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step. Cell Metab. 2, 179-189


Coward, R.J., Welsh  G.I., Yang J., Tasman C., Lennon R., Koziell A., Satchell S., Holman G.D., Kerjaschki D., Tavare J.M., Mathieson P.W. and Saleem M.A. (2005) The Human Glomerular Podocyte Is a Novel Target for Insulin Action. Diabetes 54, 3095-3102


Yang, J and Holman, G.D. (2006) Long-Term Metformin Treatment Stimulates Cardiomyocyte Glucose Transport through an AMP-Activated Protein Kinase-Dependent Reduction in GLUT4 Endocytosis. Endocrinology 147, 2728-2736


Miller, E. J., Li, J.,  Sinusas, K. M., Holman, G. D. and Young L. H. (2007) Infusion of a Biotinylated Bis-Glucose Photolabel: A New Method to Quantify Cell-Surface GLUT4 in the Intact Mouse Heart. Am.J Physiol Endocrinol.Metab, 262, E1922-E1928.


Koumanov, F. and Holman G. D. (2007) Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways. Biochem J 403, e9-e11


Holman G. D.  and Sakamoto, K. (2008) Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am.J Physiol Endocrinol.Metab. 295, E29-E37.


Sakamoto, K. and Holman G. D. (2008) Regulating the motor for GLUT4 vesicle traffic. Cell Metab. 8, 344-346.


Fazakerley D.J., Scott S.P., Lizunov V.A., Cushman S.W. and Holman G.D. (2009) A common trafficking route for GLUT4 translocation in cardiomyocytes following insulin, contraction and energy-status signalling. J. Cell Science 122, 847-854


Karlsson,H.K., Chibalin,A.V., Koistinen,H.A., Yang,J., Koumanov,F., Wallberg-Henriksson,H., Zierath,J.R. and Holman,G.D. (2009) Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle. Diabetes 58, 847-854