Carbery Research Group

Welcome to the homepage of the Carbery Research Group.

Based at the University of Bath, our research themes are primarily organic synthesis in nature, however, they focus on a wide range of specific problems covering topics such as helicity, organocatalysis, asymmetric synthesis, target orientated synthesis and development of new methodologies.

Latest News

12/01/2012:	Congratulations to Nathan for his publication in Org Lett The Ireland-Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important ß,ß’-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote stereocontrol. This strategy has been used to synthesize the natural immunosuppressant mycestericin G and ent-mycestericin G, allowing for a revision of absolute configuration of this natural product.
24/11/2011:	Congratulations to Wes for his publication in OBC α-Alkyl ß-amino esters are available in high diastereoselectivity through a silicon-free Claisen enolate [3,3]-sigmatropic rearrangement of enamide esters. Optimisation studies have probed the crucial role of the initial enolisation and the nature of the enamide N-centre. The demonstration of chirality transfer and the formation of ß-proline systems, is also presented.
02/09/2011:	Congratulations to Jim for his publication in Tetrahedron Lett The Ireland-Claisen [3,3]-sigmatropic rearrangement of an allylic glycinate bearing a remote chiral enol ether has been studied. Remote exopericyclic stereocontrol is achievable in this instance. The product from this rearrangement has been progressed through a formal total synthesis of the natural antibiotic, furanomycin.
25/03/2011:	Congratulations to Dr Wesley Harker for passing his viva!
28/02/2011:	Nathan and Matt were both accepted onto AstraZeneca's Medicinal and Process Chemistry Workshop

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