46. Rhodium-Catalysed 1,4-Additions in Water: Synthesis of Succinic Esters and Beta(2)-Amino Acid Derivatives
Synlett 2004, 2022-2024
Wadsworth, K. J.; Wood, F. K.; Chapman, C. J.; Frost, C. G.
The rhodium-catalysed addition of boronic acids to alpha-substituted activated alkenes proceeds smoothly in water resulting in a unique synthesis of both succinic esters and beta(2)-amino acid derivatives.