58. A New Method for Constructing Quaternary Carbon Centres: Tandem Rhodium-Catalysed 1,4-Addition/Intramolecular Cyclisation 2
Advanced Synthesis & Catalysis 2007, 349, 3, 432 - 440
Jérôme Le Nôtre, David van Mele, Christopher G. Frost
The tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1’-alkenes using aryl zinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loading under mild conditions. A new quaternary carbon centre is created during the cyclisation step.