50. Indium Triflate Catalysed Ene and Friedel Crafts Additions to Alpha-Imino Esters: A One-Pot Synthesis of Alpha-Amino Acid Derivatives
Letters In Organic Chemistry 2006, 3, 228-230
Chauhan, K. K.; Hartley, J. P.; Krakowski, M.; Frost, C. G.
The indium catalysed additions of electron-rich alkenes and heteroaromatics to dn activated alpha-imino ester is described. The moisture-sensitive substrate is prepared in situ facilitating a convenient synthesis of unnatural alpha-amino acid derivatives in one-pot from commercially available reagents.