39. Enantioselective Rhodium-Catalysed Addition of Boronic Acids Using C-2-Symmetric Aryl Diphosphite Ligands
Journal Of Organometallic Chemistry 2003, 680, 206-211
Chapman, C. J.; Wadsworth, K. J.; Frost, C. G.
The enantioselective rhodium-catalysed conjugate addition of aryl boronic acids to dehydroalanine derivatives has been successfully carried out in the presence of C-2-symmetric aryl diphosphite ligand (R,R,R-4) to prepare unnatural amino acid esters. The products have been obtained in up to 72% ee and with good isolated yield.